What compounds affect the CD209 (DC-SIGN) signaling pathway?

56 compounds in the BiohacksAI corpus have documented interactions with genes in the CD209 (DC-SIGN) signaling pathway (Reactome ID: R-HSA-5621575). These compounds target 11 genes within this pathway.

What genes are in the CD209 (DC-SIGN) signaling pathway?

The CD209 (DC-SIGN) signaling pathway involves 11 genes. Key genes include: CREBBP, EP300, FYN, LYN, NFKB1, PRKACA, PRKACB, PRKACG, RAF1, RELA.

CD209 (DC-SIGN) signaling

REACTOME PATHWAY

Reactome: R-HSA-562157511 genes56 compounds

The CD209 (DC-SIGN) signaling pathway (Reactome ID: R-HSA-5621575) involves 11 genes and is affected by 56 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREBBP EP300 FYN LYN NFKB1 PRKACA PRKACB PRKACG RAF1 RELA RPS6KA5

Compounds Affecting CD209 (DC-SIGN) signaling

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	egcg	—	300
3	tyrphostin ag 1478	—	4
4	Dasatinib	—	299
5	Sorafenib	—	300
6	Quercetin	—	300
7	Resveratrol	—	298
8	Bortezomib	—	300
9	Podophyllotoxin	—	14
10	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
11	Kaempferols	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Rutin	—	300
14	Withania	—	500
15	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
16	tamarixetin	—	26
17	Trifluridine	—	295
18	withaferin	—	300
19	plumbagin [Supplementary Concept]	—	300
20	Crizotinib	—	298
21	kenpaullone	—	8
22	sp600125	—	117
23	Hydrocortisone	—	299
24	Cerulenin	—	300
25	Chlorpropamide	—	300
26	daph	—	2
27	Disulfiram	—	297
28	Hexachlorophene	—	300
29	Hydrocortisone	—	298
30	Lovastatin	—	300
31	ly294002	—	11
32	Promethazine	—	121
33	protriptyline	—	296
34	streptonigrin	—	299
35	Sulfaphenazole	—	300
36	Triamcinolone	—	300
37	tyrphostin 1	—	1
38	Voriconazole	—	299
39	Cathelicidins Antimicrobial cationic peptides with	—	300
40	Ursolic Acid	—	300
41	chicoric acid	—	117
42	Oleanolic Acid	—	300
43	pyrrolidine dithiocarbamate	—	275
44	vinblastine sulfate	—	81
45	Rosmarinic Acid	—	300
46	Genistein	—	300
47	Acetic Acid Product of	—	300
48	alsterpaullone	—	12
49	Papaverine	—	299
50	Colchicine	—	300

About the CD209 (DC-SIGN) signaling Pathway

The CD209 (DC-SIGN) signaling pathway is catalogued in Reactome (ID: R-HSA-5621575) and involves 11 genes. In the BiohacksAI corpus, 56 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREBBP, EP300, FYN, LYN, NFKB1.