What compounds affect the Deubiquitination pathway?

556 compounds in the BiohacksAI corpus have documented interactions with genes in the Deubiquitination pathway (Reactome ID: R-HSA-5688426). These compounds target 79 genes within this pathway.

What genes are in the Deubiquitination pathway?

The Deubiquitination pathway involves 79 genes. Key genes include: ADRB2, ADRM1, AR, ARRB1, BAP1, BARD1, BRCA1, CCNA1, CDC25A, CDK1.

Deubiquitination

REACTOME PATHWAY

Reactome: R-HSA-568842679 genes556 compounds

The Deubiquitination pathway (Reactome ID: R-HSA-5688426) involves 79 genes and is affected by 556 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRB2 ADRM1 AR ARRB1 BAP1 BARD1 BRCA1 CCNA1 CDC25A CDK1 CFTR EP300 ESR1 HIF1A IDE KAT2A KAT2B MAP3K7 MDM2 MDM4 MYC NEDD8 NFKBIA NLRP3 NOD1 NOD2 OTUD3 POLB PRKN PSMA1+49 more

Compounds Affecting Deubiquitination

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Quercetin	—	300
4	Hexachlorophene	—	300
5	cycloheximide	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Niclosamide	—	299
9	Disulfiram	—	297
10	vinblastine sulfate	—	81
11	Nisoldipine	—	297
12	Astemizole Antihistamine drug now withdrawn from	—	280
13	Oxyphenbutazone	—	300
14	rafoxanide	—	172
15	alpha-Linolenic Acid	—	300
16	Digoxin	—	299
17	Chlorhexidine	—	299
18	Methylene Blue	—	200
19	Dinitrochlorobenzene	—	300
20	Colchicine	—	300
21	Ciclopirox	—	88
22	Podophyllotoxin	—	14
23	egcg	—	300
24	Nocodazole Nocodazole is	—	215
25	celastrol	—	300
26	Azacitidine	—	298
27	Azacitidine	—	300
28	Dasatinib	—	299
29	chrysin	—	300
30	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
31	Fluspirilene	—	74
32	Anisomycin	—	247
33	Ethidium	—	300
34	Clotrimazole	—	296
35	Loratadine	—	296
36	Melphalan	—	300
37	Demecolcine	—	246
38	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
39	Thioridazine	—	35
40	sp600125	—	117
41	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
42	Tubercidin	—	300
43	Calcimycin	—	216
44	piceatannol	—	300
45	Ethinyl Estradiol	—	300
46	Ouabain	—	300
47	Dactinomycin	—	297
48	Resveratrol	—	298
49	Rotenone	—	300
50	Digitoxin	—	300

About the Deubiquitination Pathway

The Deubiquitination pathway is catalogued in Reactome (ID: R-HSA-5688426) and involves 79 genes. In the BiohacksAI corpus, 556 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRB2, ADRM1, AR, ARRB1, BAP1.