What compounds affect the Nonhomologous End-Joining (NHEJ) pathway?

208 compounds in the BiohacksAI corpus have documented interactions with genes in the Nonhomologous End-Joining (NHEJ) pathway (Reactome ID: R-HSA-5693571). These compounds target 8 genes within this pathway.

What genes are in the Nonhomologous End-Joining (NHEJ) pathway?

The Nonhomologous End-Joining (NHEJ) pathway involves 8 genes. Key genes include: ATM, BARD1, BRCA1, NSD2, POLL, PRKDC, TDP2, UBE2N.

Nonhomologous End-Joining (NHEJ)

REACTOME PATHWAY

Reactome: R-HSA-56935718 genes208 compounds

The Nonhomologous End-Joining (NHEJ) pathway (Reactome ID: R-HSA-5693571) involves 8 genes and is affected by 208 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM BARD1 BRCA1 NSD2 POLL PRKDC TDP2 UBE2N

Compounds Affecting Nonhomologous End-Joining (NHEJ)

#	Compound	Targets Hit	Studies
1	Chlorhexidine	—	299
2	Astemizole Antihistamine drug now withdrawn from	—	280
3	Methotrexate	—	289
4	Colchicine	—	300
5	cycloheximide	—	300
6	Melphalan	—	300
7	Nocodazole Nocodazole is	—	215
8	Podophyllotoxin	—	14
9	Trifluridine	—	295
10	vinblastine sulfate	—	81
11	Azacitidine	—	298
12	Azacitidine	—	300
13	Ciclopirox	—	88
14	Cytarabine	—	297
15	Demecolcine	—	246
16	Fluspirilene	—	74
17	Hexachlorophene	—	300
18	lidoflazine	—	278
19	Niclosamide	—	299
20	Calcimycin	—	216
21	Methylene Blue	—	200
22	Ethidium	—	300
23	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
24	Sertraline	—	1,000
25	Perphenazine	—	297
26	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
27	Resveratrol	—	298
28	colchine	—	2
29	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
30	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
31	dihydrorotenone	—	13
32	gedunin	—	54
33	paxilline	—	42
34	rafoxanide	—	172
35	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
36	Tubercidin	—	300
37	Dasatinib	—	299
38	Axitinib	—	298
39	Azathioprine	—	300
40	Bortezomib	—	300
41	Crizotinib	—	298
42	Disulfiram	—	297
43	Ouabain	—	300
44	Maprotiline	—	299
45	Atorvastatin	—	1,000
46	ag490	—	14
47	alpelisib	—	227
48	Calcitriol	—	300
49	Clofarabine	—	298
50	Decitabine	—	298

About the Nonhomologous End-Joining (NHEJ) Pathway

The Nonhomologous End-Joining (NHEJ) pathway is catalogued in Reactome (ID: R-HSA-5693571) and involves 8 genes. In the BiohacksAI corpus, 208 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, BARD1, BRCA1, NSD2, POLL.