Paradoxical activation of RAF signaling by kinase inactive BRAF

Q: What compounds affect the Paradoxical activation of RAF signaling by kinase inactive BRAF pathway?

53 compounds in the BiohacksAI corpus have documented interactions with genes in the Paradoxical activation of RAF signaling by kinase inactive BRAF pathway (Reactome ID: R-HSA-6802955). These compounds target 17 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-680295517 genes53 compounds

The Paradoxical activation of RAF signaling by kinase inactive BRAF pathway (Reactome ID: R-HSA-6802955) involves 17 genes and is affected by 53 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARAF ARRB1 BRAF CAMK2B CAMK2D CSK ITGA2B ITGB3 JAK2 MAP2K1 MAP2K2 MAPK1 MAPK3 MARK3 RAF1 SRC YWHAB

Compounds Affecting Paradoxical activation of RAF signaling by kinase inactive BRAF

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	alsterpaullone	—	12
4	Vemurafenib	—	298
5	pd98059	—	7
6	kenpaullone	—	8
7	sp600125	—	117
8	trametinib	—	296
9	Quercetin	—	300
10	Axitinib	—	298
11	plumbagin [Supplementary Concept]	—	300
12	tyrphostin ag 1478	—	4
13	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
14	withaferin	—	300
15	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
16	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
17	Clotrimazole	—	296
18	fisetin	—	78
19	Progesterone	—	299
20	2-Chloroadenosine 2-Chloroadenosine.	—	300
21	Benzalkonium Compounds	—	299
22	Calcimycin	—	216
23	daph	—	2
24	Diphenhydramine	—	14
25	ha1004	—	4
26	Lithocholic Acid	—	300
27	Loratadine	—	296
28	trequinsin hydrochloride	—	1
29	Azauridine	—	300
30	Cladribine	—	297
31	Methylene Blue	—	200
32	2-Methoxyestradiol	—	300
33	Astemizole Antihistamine drug now withdrawn from	—	280
34	Azathioprine	—	300
35	Calcitriol	—	300
36	Camptothecin	—	300
37	Cytarabine	—	297
38	dihydrorotenone	—	13
39	Podophyllotoxin	—	14
40	streptonigrin	—	299
41	Trifluridine	—	295
42	Tripterygium	—	300
43	Resveratrol	—	298
44	Adenosine Monophosphate Adenine nucleotide containing	—	300
45	Afatinib	—	297
46	Crizotinib	—	298
47	monorden	—	8
48	Niclosamide	—	299
49	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
50	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300

About the Paradoxical activation of RAF signaling by kinase inactive BRAF Pathway

The Paradoxical activation of RAF signaling by kinase inactive BRAF pathway is catalogued in Reactome (ID: R-HSA-6802955) and involves 17 genes. In the BiohacksAI corpus, 53 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARAF, ARRB1, BRAF, CAMK2B, CAMK2D.