Regulation of TP53 Activity through Phosphorylation

Q: What compounds affect the Regulation of TP53 Activity through Phosphorylation pathway?

223 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of TP53 Activity through Phosphorylation pathway (Reactome ID: R-HSA-6804756). These compounds target 37 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-680475637 genes223 compounds

The Regulation of TP53 Activity through Phosphorylation pathway (Reactome ID: R-HSA-6804756) involves 37 genes and is affected by 223 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM AURKA AURKB BARD1 BLM BRCA1 CCNA1 CDK2 CDK5 CDK5R1 CHEK1 CHEK2 CSNK2A1 CSNK2A2 CSNK2B DNA2 DYRK2 HIPK1 HIPK2 MAPK11 MAPK14 MAPKAPK5 MDM2 MDM4 NUAK1 PIN1 PLK3 PRKAA1 PRKAA2 PRKAB1+7 more

Compounds Affecting Regulation of TP53 Activity through Phosphorylation

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Niclosamide	—	299
3	Quercetin	—	300
4	Ursolic Acid	—	300
5	kenpaullone	—	8
6	Rotenone	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Antimycin	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
11	Sorafenib	—	300
12	fisetin	—	78
13	Adenosine Monophosphate Adenine nucleotide containing	—	300
14	Proguanil	—	299
15	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
16	Berberine	—	300
17	Oleanolic Acid	—	300
18	Metformin	—	1,000
19	chrysin	—	300
20	alsterpaullone	—	12
21	Hexachlorophene	—	300
22	Azacitidine	—	298
23	Azacitidine	—	300
24	Methylene Blue	—	200
25	Cytarabine	—	297
26	Melphalan	—	300
27	Methotrexate	—	289
28	Trifluridine	—	295
29	Ciclopirox	—	88
30	cycloheximide	—	300
31	vinblastine sulfate	—	81
32	Nocodazole Nocodazole is	—	215
33	rafoxanide	—	172
34	Astemizole Antihistamine drug now withdrawn from	—	280
35	Chlorhexidine	—	299
36	Colchicine	—	300
37	Demecolcine	—	246
38	Kaempferols	—	300
39	ly294002	—	11
40	egcg	—	300
41	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
42	Axitinib	—	298
43	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
44	Dasatinib	—	299
45	Calcimycin	—	216
46	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
47	Tubercidin	—	300
48	Anisomycin	—	247
49	colchine	—	2
50	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300

About the Regulation of TP53 Activity through Phosphorylation Pathway

The Regulation of TP53 Activity through Phosphorylation pathway is catalogued in Reactome (ID: R-HSA-6804756) and involves 37 genes. In the BiohacksAI corpus, 223 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, AURKA, AURKB, BARD1, BLM.