What genes are in the Regulation of TP53 Activity through Methylation pathway?

The Regulation of TP53 Activity through Methylation pathway involves 12 genes. Key genes include: ATM, CHEK2, EHMT1, EHMT2, EP300, KMT5A, L3MBTL1, MDM2, MDM4, PRMT5.

Regulation of TP53 Activity through Methylation

Q: What compounds affect the Regulation of TP53 Activity through Methylation pathway?

193 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of TP53 Activity through Methylation pathway (Reactome ID: R-HSA-6804760). These compounds target 12 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-680476012 genes193 compounds

The Regulation of TP53 Activity through Methylation pathway (Reactome ID: R-HSA-6804760) involves 12 genes and is affected by 193 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ATM CHEK2 EHMT1 EHMT2 EP300 KMT5A L3MBTL1 MDM2 MDM4 PRMT5 SMYD2 TP53

Compounds Affecting Regulation of TP53 Activity through Methylation

#	Compound	Targets Hit	Studies
1	Methylene Blue	—	200
2	sp600125	—	117
3	streptonigrin	—	299
4	s adenosylhomocysteine	—	300
5	Hexachlorophene	—	300
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Cladribine	—	297
9	Cytarabine	—	297
10	Melphalan	—	300
11	Niclosamide	—	299
12	Methotrexate	—	289
13	Disulfiram	—	297
14	Trifluridine	—	295
15	ninhydrin	—	300
16	Ciclopirox	—	88
17	cycloheximide	—	300
18	Dinitrochlorobenzene	—	300
19	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
20	Vorinostat	—	299
21	Spironolactone	—	298
22	Thioridazine	—	35
23	vinblastine sulfate	—	81
24	Digoxin	—	299
25	Nisoldipine	—	297
26	Nocodazole Nocodazole is	—	215
27	Oxyphenbutazone	—	300
28	rafoxanide	—	172
29	Sertraline	—	1,000
30	Astemizole Antihistamine drug now withdrawn from	—	280
31	Chlorhexidine	—	299
32	Colchicine	—	300
33	Demecolcine	—	246
34	tyrphostin 9	—	2
35	Lovastatin	—	300
36	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
37	plumbagin [Supplementary Concept]	—	300
38	Nitrofurantoin	—	297
39	Calcimycin	—	216
40	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
41	Tubercidin	—	300
42	Anisomycin	—	247
43	colchine	—	2
44	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
45	Fluspirilene	—	74
46	gedunin	—	54
47	lidoflazine	—	278
48	Ouabain	—	300
49	paxilline	—	42
50	Podophyllotoxin	—	14

About the Regulation of TP53 Activity through Methylation Pathway

The Regulation of TP53 Activity through Methylation pathway is catalogued in Reactome (ID: R-HSA-6804760) and involves 12 genes. In the BiohacksAI corpus, 193 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ATM, CHEK2, EHMT1, EHMT2, EP300.