What compounds affect the Mitotic Prophase pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitotic Prophase pathway (Reactome ID: R-HSA-68875). These compounds target 12 genes within this pathway.

What genes are in the Mitotic Prophase pathway?

The Mitotic Prophase pathway involves 12 genes. Key genes include: CCNB1, CCNB2, CDK1, KMT5A, LMNA, MAPK1, MAPK3, NEK6, NEK7, NEK9.

Mitotic Prophase

REACTOME PATHWAY

Reactome: R-HSA-6887512 genes47 compounds

The Mitotic Prophase pathway (Reactome ID: R-HSA-68875) involves 12 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNB1 CCNB2 CDK1 KMT5A LMNA MAPK1 MAPK3 NEK6 NEK7 NEK9 PLK1 PPP2CA

Compounds Affecting Mitotic Prophase

#	Compound	Targets Hit	Studies
1	alsterpaullone	—	12
2	kenpaullone	—	8
3	fisetin	—	78
4	Sorafenib	—	300
5	indirubin	—	300
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	chrysin	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Quercetin	—	300
10	plumbagin [Supplementary Concept]	—	300
11	pd98059	—	7
12	Clotrimazole	—	296
13	sp600125	—	117
14	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
15	Lithocholic Acid	—	300
16	trametinib	—	296
17	withaferin	—	300
18	Crizotinib	—	298
19	tyrphostin ag 1478	—	4
20	Progesterone	—	299
21	2-Chloroadenosine 2-Chloroadenosine.	—	300
22	Benzalkonium Compounds	—	299
23	Calcimycin	—	216
24	daph	—	2
25	Diphenhydramine	—	14
26	ha1004	—	4
27	Loratadine	—	296
28	trequinsin hydrochloride	—	1
29	Clofibrate	—	299
30	Fenofibrate	—	297
31	Sertraline	—	1,000
32	Cinnarizine	—	299
33	Rotenone	—	300
34	ly294002	—	11
35	Wortmannin	—	300
36	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
37	Oleic Acid	—	112
38	Simvastatin	—	1,000
39	cefaclor	—	299
40	Disulfiram	—	297
41	Hexachlorophene	—	300
42	Nisoldipine	—	297
43	Oxyphenbutazone	—	300
44	Oxytetracycline	—	300
45	Cyproheptadine	—	299
46	Histamine	—	300
47	Okadaic Acid	—	300

About the Mitotic Prophase Pathway

The Mitotic Prophase pathway is catalogued in Reactome (ID: R-HSA-68875) and involves 12 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CCNB2, CDK1, KMT5A, LMNA.