What compounds affect the G2/M Checkpoints pathway?

305 compounds in the BiohacksAI corpus have documented interactions with genes in the G2/M Checkpoints pathway (Reactome ID: R-HSA-69481). These compounds target 55 genes within this pathway.

What genes are in the G2/M Checkpoints pathway?

The G2/M Checkpoints pathway involves 55 genes. Key genes include: ADRM1, ATM, BARD1, BLM, BRCA1, CCNA1, CCNB1, CCNB2, CDC25A, CDC7.

G2/M Checkpoints

REACTOME PATHWAY

Reactome: R-HSA-6948155 genes305 compounds

The G2/M Checkpoints pathway (Reactome ID: R-HSA-69481) involves 55 genes and is affected by 305 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ATM BARD1 BLM BRCA1 CCNA1 CCNB1 CCNB2 CDC25A CDC7 CDK1 CDK2 CHEK1 CHEK2 DNA2 NSD2 PKMYT1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6+25 more

Compounds Affecting G2/M Checkpoints

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	sp600125	—	117
5	alsterpaullone	—	12
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	chrysin	—	300
9	Quercetin	—	300
10	Chlorhexidine	—	299
11	Astemizole Antihistamine drug now withdrawn from	—	280
12	indirubin	—	300
13	Methylene Blue	—	200
14	Methotrexate	—	289
15	Colchicine	—	300
16	cycloheximide	—	300
17	Melphalan	—	300
18	Nocodazole Nocodazole is	—	215
19	Trifluridine	—	295
20	vinblastine sulfate	—	81
21	Sertraline	—	1,000
22	Azacitidine	—	298
23	Azacitidine	—	300
24	Ciclopirox	—	88
25	Cytarabine	—	297
26	Demecolcine	—	246
27	Hexachlorophene	—	300
28	Idarubicin	—	299
29	Niclosamide	—	299
30	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
31	Vitamin K 3	—	300
32	Dasatinib	—	299
33	Disulfiram	—	297
34	Ethidium	—	300
35	Podophyllotoxin	—	14
36	Daunorubicin	—	298
37	Clotrimazole	—	296
38	Fluspirilene	—	74
39	lidoflazine	—	278
40	Perphenazine	—	297
41	Rotenone	—	300
42	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
43	Resveratrol	—	298
44	rafoxanide	—	172
45	fisetin	—	78
46	Axitinib	—	298
47	Azathioprine	—	300
48	Maprotiline	—	299
49	Clofarabine	—	298
50	Decitabine	—	298

About the G2/M Checkpoints Pathway

The G2/M Checkpoints pathway is catalogued in Reactome (ID: R-HSA-69481) and involves 55 genes. In the BiohacksAI corpus, 305 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ATM, BARD1, BLM, BRCA1.