What compounds affect the Cell Cycle Checkpoints pathway?

326 compounds in the BiohacksAI corpus have documented interactions with genes in the Cell Cycle Checkpoints pathway (Reactome ID: R-HSA-69620). These compounds target 75 genes within this pathway.

What genes are in the Cell Cycle Checkpoints pathway?

The Cell Cycle Checkpoints pathway involves 75 genes. Key genes include: ADRM1, ATM, AURKB, BARD1, BIRC5, BLM, BRCA1, CCNA1, CCNB1, CCNB2.

Cell Cycle Checkpoints

REACTOME PATHWAY

Reactome: R-HSA-6962075 genes326 compounds

The Cell Cycle Checkpoints pathway (Reactome ID: R-HSA-69620) involves 75 genes and is affected by 326 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 ATM AURKB BARD1 BIRC5 BLM BRCA1 CCNA1 CCNB1 CCNB2 CCNE2 CDC25A CDC7 CDK1 CDK2 CHEK1 CHEK2 CSNK1A1 CSNK1E CUL1 DNA2 GSK3B MAPK11 MAPK14 MDM2 MDM4 NEK11 NSD2 PKMYT1 PLK1+45 more

Compounds Affecting Cell Cycle Checkpoints

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	sp600125	—	117
3	Reserpine	—	297
4	kenpaullone	—	8
5	Quercetin	—	300
6	alsterpaullone	—	12
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Dasatinib	—	299
10	Sorafenib	—	300
11	Chlorhexidine	—	299
12	chrysin	—	300
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	Hexachlorophene	—	300
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Methylene Blue	—	200
17	Methotrexate	—	289
18	Colchicine	—	300
19	cycloheximide	—	300
20	Melphalan	—	300
21	Nocodazole Nocodazole is	—	215
22	Trifluridine	—	295
23	vinblastine sulfate	—	81
24	Sertraline	—	1,000
25	Azacitidine	—	298
26	Azacitidine	—	300
27	Ciclopirox	—	88
28	Cytarabine	—	297
29	Demecolcine	—	246
30	indirubin	—	300
31	Niclosamide	—	299
32	fisetin	—	78
33	Podophyllotoxin	—	14
34	Fluspirilene	—	74
35	lidoflazine	—	278
36	Oxyphenbutazone	—	300
37	Vitamin K 3	—	300
38	Nisoldipine	—	297
39	rafoxanide	—	172
40	Disulfiram	—	297
41	Digoxin	—	299
42	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
43	withaferin	—	300
44	Lovastatin	—	300
45	Simvastatin	—	1,000
46	Afatinib	—	297
47	Cladribine	—	297
48	Idarubicin	—	299
49	ly294002	—	11
50	Thioridazine	—	35

About the Cell Cycle Checkpoints Pathway

The Cell Cycle Checkpoints pathway is catalogued in Reactome (ID: R-HSA-69620) and involves 75 genes. In the BiohacksAI corpus, 326 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, ATM, AURKB, BARD1, BIRC5.