What compounds affect the DNA Repair pathway?

348 compounds in the BiohacksAI corpus have documented interactions with genes in the DNA Repair pathway (Reactome ID: R-HSA-73894). These compounds target 50 genes within this pathway.

What genes are in the DNA Repair pathway?

The DNA Repair pathway involves 50 genes. Key genes include: ABL1, ALKBH5, APEX1, ATM, BAP1, BARD1, BLM, BRCA1, CCNA1, CDK2.

DNA Repair

REACTOME PATHWAY

Reactome: R-HSA-7389450 genes348 compounds

The DNA Repair pathway (Reactome ID: R-HSA-73894) involves 50 genes and is affected by 348 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ALKBH5 APEX1 ATM BAP1 BARD1 BLM BRCA1 CCNA1 CDK2 CDK7 CHEK1 CHEK2 COPS5 DNA2 ERCC3 EYA2 FEN1 FTO KDM4A KDM4B MAPK8 MPG MUS81 NSD2 OGG1 PARP1 PCNA POLB POLH+20 more

Compounds Affecting DNA Repair

#	Compound	Targets Hit	Studies
1	Aurintricarboxylic Acid	—	184
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	Quercetin	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Ethidium	—	300
6	Hexachlorophene	—	300
7	Idarubicin	—	299
8	sp600125	—	117
9	Oxytetracycline	—	300
10	streptonigrin	—	299
11	Methylene Blue	—	200
12	Methotrexate	—	289
13	Chlorhexidine	—	299
14	piceatannol	—	300
15	alpha-Linolenic Acid	—	300
16	Nocodazole Nocodazole is	—	215
17	Daunorubicin	—	298
18	kenpaullone	—	8
19	Levodopa	—	297
20	alsterpaullone	—	12
21	Astemizole Antihistamine drug now withdrawn from	—	280
22	Demecolcine	—	246
23	Diiodotyrosine	—	300
24	Methyldopa	—	297
25	Norepinephrine Precursor of epinephrine that is secreted by	—	298
26	Axitinib	—	298
27	Bortezomib	—	300
28	Colchicine	—	300
29	cycloheximide	—	300
30	Melphalan	—	300
31	Podophyllotoxin	—	14
32	Trifluridine	—	295
33	vinblastine sulfate	—	81
34	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
35	Azacitidine	—	298
36	Azacitidine	—	300
37	celastrol	—	300
38	Ciclopirox	—	88
39	Cytarabine	—	297
40	Niclosamide	—	299
41	Perphenazine	—	297
42	triolimus [Supplementary Concept]	—	33
43	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
44	Resveratrol	—	298
45	Estramustine	—	300
46	Demeclocycline	—	5
47	rafoxanide	—	172
48	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
49	Carmine Coloring matter from	—	300
50	Masoprocol	—	300

About the DNA Repair Pathway

The DNA Repair pathway is catalogued in Reactome (ID: R-HSA-73894) and involves 50 genes. In the BiohacksAI corpus, 348 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ALKBH5, APEX1, ATM, BAP1.