Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

Q: What compounds affect the Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models pathway?

120 compounds in the BiohacksAI corpus have documented interactions with genes in the Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models pathway (Reactome ID: R-HSA-8862803). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-886280311 genes120 compounds

The Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models pathway (Reactome ID: R-HSA-8862803) involves 11 genes and is affected by 120 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP BCL2L11 CAPN1 CDC25A CDC25B CDK5 CDK5R1 FOXO3 JUN LMNA PRDX1

Compounds Affecting Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Vitamin K 3	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Disulfiram	—	297
6	Methylene Blue	—	200
7	Podophyllotoxin	—	14
8	Resveratrol	—	298
9	kenpaullone	—	8
10	alsterpaullone	—	12
11	indirubin	—	300
12	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
13	chrysin	—	300
14	fisetin	—	78
15	plumbagin [Supplementary Concept]	—	300
16	Colchicine	—	300
17	DEAD-box RNA Helicases	—	169
18	Thioctic Acid	—	298
19	Diphenhydramine	—	14
20	glaucarubinone	—	10
21	Thioctic Acid	—	300
22	vinblastine sulfate	—	81
23	Amoxapine	—	259
24	Cinnarizine	—	299
25	Clofibrate	—	299
26	Ethoxyquin Antioxidant; also	—	180
27	Fenofibrate	—	297
28	Lithocholic Acid	—	300
29	Lovastatin	—	300
30	Lynestrenol	—	299
31	Medroxyprogesterone Acetate	—	299
32	Mestranol	—	300
33	Phenoxybenzamine	—	21
34	Promethazine	—	121
35	triflupromazine hydrochloride	—	12
36	Vincamine	—	300
37	Azithromycin	—	1,000
38	Budesonide	—	1,000
39	Fluoxetine	—	1,000
40	Iodine	—	300
41	Mianserin	—	299
42	Sertraline	—	1,000
43	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
44	Taurine	—	300
45	vinpocetine	—	299
46	Bupranolol	—	291
47	Chlormadinone Acetate	—	300
48	Clotrimazole	—	296
49	Cyproheptadine	—	299
50	Desoxycorticosterone	—	300

About the Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Pathway

The Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models pathway is catalogued in Reactome (ID: R-HSA-8862803) and involves 11 genes. In the BiohacksAI corpus, 120 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BCL2L11, CAPN1, CDC25A, CDC25B.