What compounds affect the Neurodegenerative Diseases pathway?

120 compounds in the BiohacksAI corpus have documented interactions with genes in the Neurodegenerative Diseases pathway (Reactome ID: R-HSA-8863678). These compounds target 11 genes within this pathway.

What genes are in the Neurodegenerative Diseases pathway?

The Neurodegenerative Diseases pathway involves 11 genes. Key genes include: APP, BCL2L11, CAPN1, CDC25A, CDC25B, CDK5, CDK5R1, FOXO3, JUN, LMNA.

Neurodegenerative Diseases

REACTOME PATHWAY

Reactome: R-HSA-886367811 genes120 compounds

The Neurodegenerative Diseases pathway (Reactome ID: R-HSA-8863678) involves 11 genes and is affected by 120 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APP BCL2L11 CAPN1 CDC25A CDC25B CDK5 CDK5R1 FOXO3 JUN LMNA PRDX1

Compounds Affecting Neurodegenerative Diseases

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Vitamin K 3	—	300
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Disulfiram	—	297
6	Methylene Blue	—	200
7	Podophyllotoxin	—	14
8	Resveratrol	—	298
9	kenpaullone	—	8
10	alsterpaullone	—	12
11	indirubin	—	300
12	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
13	chrysin	—	300
14	fisetin	—	78
15	plumbagin [Supplementary Concept]	—	300
16	Colchicine	—	300
17	DEAD-box RNA Helicases	—	169
18	Thioctic Acid	—	298
19	Diphenhydramine	—	14
20	glaucarubinone	—	10
21	Thioctic Acid	—	300
22	vinblastine sulfate	—	81
23	Amoxapine	—	259
24	Cinnarizine	—	299
25	Clofibrate	—	299
26	Ethoxyquin Antioxidant; also	—	180
27	Fenofibrate	—	297
28	Lithocholic Acid	—	300
29	Lovastatin	—	300
30	Lynestrenol	—	299
31	Medroxyprogesterone Acetate	—	299
32	Mestranol	—	300
33	Phenoxybenzamine	—	21
34	Promethazine	—	121
35	triflupromazine hydrochloride	—	12
36	Vincamine	—	300
37	Azithromycin	—	1,000
38	Budesonide	—	1,000
39	Fluoxetine	—	1,000
40	Iodine	—	300
41	Mianserin	—	299
42	Sertraline	—	1,000
43	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
44	Taurine	—	300
45	vinpocetine	—	299
46	Bupranolol	—	291
47	Chlormadinone Acetate	—	300
48	Clotrimazole	—	296
49	Cyproheptadine	—	299
50	Desoxycorticosterone	—	300

About the Neurodegenerative Diseases Pathway

The Neurodegenerative Diseases pathway is catalogued in Reactome (ID: R-HSA-8863678) and involves 11 genes. In the BiohacksAI corpus, 120 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BCL2L11, CAPN1, CDC25A, CDC25B.