What compounds affect the Downregulation of ERBB2 signaling pathway?

40 compounds in the BiohacksAI corpus have documented interactions with genes in the Downregulation of ERBB2 signaling pathway (Reactome ID: R-HSA-8863795). These compounds target 9 genes within this pathway.

What genes are in the Downregulation of ERBB2 signaling pathway?

The Downregulation of ERBB2 signaling pathway involves 9 genes. Key genes include: AKT3, CDC37, EGFR, ERBB2, ERBB3, ERBB4, HSP90AA1, MATK, USP8.

Downregulation of ERBB2 signaling

REACTOME PATHWAY

Reactome: R-HSA-88637959 genes40 compounds

The Downregulation of ERBB2 signaling pathway (Reactome ID: R-HSA-8863795) involves 9 genes and is affected by 40 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 CDC37 EGFR ERBB2 ERBB3 ERBB4 HSP90AA1 MATK USP8

Compounds Affecting Downregulation of ERBB2 signaling

#	Compound	Targets Hit	Studies
1	Afatinib	—	297
2	celastrol	—	300
3	Dasatinib	—	299
4	tyrphostin ag 1478	—	4
5	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
6	Quercetin	—	300
7	ag490	—	14
8	sp600125	—	117
9	triolimus [Supplementary Concept]	—	33
10	monorden	—	8
11	gedunin	—	54
12	Novobiocin	—	300
13	caffeic acid	—	300
14	Masoprocol	—	300
15	Tetracycline	—	300
16	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	2-Chloroadenosine 2-Chloroadenosine.	—	300
19	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
20	Calcimycin	—	216
21	Calcitriol	—	300
22	Ciclopirox	—	88
23	Clotrimazole	—	296
24	cycloheximide	—	300
25	deguelin [Supplementary Concept]	—	151
26	Disulfiram	—	297
27	Hexachlorophene	—	300
28	Idarubicin	—	299
29	Indazoles	—	300
30	Miconazole	—	298
31	piceatannol	—	300
32	Nitroprusside	—	299
33	specioside	—	6
34	Wortmannin	—	300
35	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
36	Adapalene	—	296
37	alpha-Linolenic Acid	—	300
38	prunetin	—	35
39	tyrphostin 1	—	1
40	hydroxyfasudil [Supplementary Concept]	—	11

About the Downregulation of ERBB2 signaling Pathway

The Downregulation of ERBB2 signaling pathway is catalogued in Reactome (ID: R-HSA-8863795) and involves 9 genes. In the BiohacksAI corpus, 40 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, CDC37, EGFR, ERBB2, ERBB3.