What compounds affect the Regulation of PTEN gene transcription pathway?

273 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of PTEN gene transcription pathway (Reactome ID: R-HSA-8943724). These compounds target 17 genes within this pathway.

What genes are in the Regulation of PTEN gene transcription pathway?

The Regulation of PTEN gene transcription pathway involves 17 genes. Key genes include: EED, EZH2, HDAC1, HDAC2, HDAC3, HDAC5, HDAC7, JUN, KDM1A, MAPK1.

Regulation of PTEN gene transcription

REACTOME PATHWAY

Reactome: R-HSA-894372417 genes273 compounds

The Regulation of PTEN gene transcription pathway (Reactome ID: R-HSA-8943724) involves 17 genes and is affected by 273 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EED EZH2 HDAC1 HDAC2 HDAC3 HDAC5 HDAC7 JUN KDM1A MAPK1 MAPK3 MLST8 MTOR NR2E1 PPARG RPTOR TP53

Compounds Affecting Regulation of PTEN gene transcription

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Camptothecin	—	300
3	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
4	Vorinostat	—	299
5	pictilisib	—	25
6	Ursolic Acid	—	300
7	scriptaid	—	53
8	Valproic Acid	—	296
9	Butyric Acid	—	300
10	Celecoxib	—	295
11	Bortezomib	—	300
12	Rotenone	—	300
13	Disulfiram	—	297
14	Quercetin	—	300
15	Clotrimazole	—	296
16	Ku 0063794 [Supplementary Concept]	—	7
17	Maprotiline	—	299
18	Methylene Blue	—	200
19	plumbagin [Supplementary Concept]	—	300
20	Loratadine	—	296
21	Thioridazine	—	35
22	vinblastine sulfate	—	81
23	Fenofibrate	—	297
24	Nocodazole Nocodazole is	—	215
25	pd98059	—	7
26	triflupromazine hydrochloride	—	12
27	Astemizole Antihistamine drug now withdrawn from	—	280
28	withaferin	—	300
29	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
30	Sirolimus	—	300
31	torin 1	—	10
32	Everolimus	—	297
33	Sorafenib	—	300
34	Ethidium	—	300
35	Hexachlorophene	—	300
36	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
37	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
38	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
39	Niclosamide	—	299
40	Methotrexate	—	289
41	Dactinomycin	—	297
42	Glutaral	—	42
43	Vitamin K 3	—	300
44	ninhydrin	—	300
45	o-Phthalaldehyde	—	300
46	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
47	Genistein	—	300
48	Resveratrol	—	298
49	cycloheximide	—	300
50	daph	—	2

About the Regulation of PTEN gene transcription Pathway

The Regulation of PTEN gene transcription pathway is catalogued in Reactome (ID: R-HSA-8943724) and involves 17 genes. In the BiohacksAI corpus, 273 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EED, EZH2, HDAC1, HDAC2, HDAC3.