What compounds affect the Neddylation pathway?

261 compounds in the BiohacksAI corpus have documented interactions with genes in the Neddylation pathway (Reactome ID: R-HSA-8951664). These compounds target 49 genes within this pathway.

What genes are in the Neddylation pathway?

The Neddylation pathway involves 49 genes. Key genes include: ADRM1, BIRC5, BRCA1, COPS5, CUL1, EPAS1, HIF1A, NAE1, NEDD8, NFE2L2.

Neddylation

REACTOME PATHWAY

Reactome: R-HSA-895166449 genes261 compounds

The Neddylation pathway (Reactome ID: R-HSA-8951664) involves 49 genes and is affected by 261 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 BIRC5 BRCA1 COPS5 CUL1 EPAS1 HIF1A NAE1 NEDD8 NFE2L2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6+19 more

Compounds Affecting Neddylation

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	candesartan cilexetil [Supplementary Concept]	—	300
5	Resveratrol	—	298
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	Niclosamide	—	299
8	Podophyllotoxin	—	14
9	ninhydrin	—	300
10	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
11	sp600125	—	117
12	Quercetin	—	300
13	chrysin	—	300
14	Digoxin	—	299
15	Hexachlorophene	—	300
16	Clotrimazole	—	296
17	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
18	cycloheximide	—	300
19	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
20	egcg	—	300
21	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
22	gedunin	—	54
23	Tubercidin	—	300
24	piceatannol	—	300
25	Colchicine	—	300
26	Azacitidine	—	298
27	Azacitidine	—	300
28	Genistein	—	300
29	Methylene Blue	—	200
30	Ethoxyquin Antioxidant; also	—	180
31	vinblastine sulfate	—	81
32	Vitamin K 3	—	300
33	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
34	DEAD-box RNA Helicases	—	169
35	Thioctic Acid	—	298
36	amlexanox	—	96
37	Ethidium	—	300
38	Leflunomide	—	297
39	Nocodazole Nocodazole is	—	215
40	Oxyphenbutazone	—	300
41	Thioctic Acid	—	300
42	Methotrexate	—	289
43	Lithocholic Acid	—	300
44	Nisoldipine	—	297
45	Kaempferols	—	300
46	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
47	Disulfiram	—	297
48	Loratadine	—	296
49	Melphalan	—	300
50	Mometasone Furoate	—	292

About the Neddylation Pathway

The Neddylation pathway is catalogued in Reactome (ID: R-HSA-8951664) and involves 49 genes. In the BiohacksAI corpus, 261 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, BIRC5, BRCA1, COPS5, CUL1.