What compounds affect the Signaling by TGFB family members pathway?

255 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by TGFB family members pathway (Reactome ID: R-HSA-9006936). These compounds target 46 genes within this pathway.

What genes are in the Signaling by TGFB family members pathway?

The Signaling by TGFB family members pathway involves 46 genes. Key genes include: ACVR1B, ACVR2A, ACVR2B, ACVRL1, AGO2, APH1A, APH1B, ARRB1, BMPR1B, CCNC.

Signaling by TGFB family members

REACTOME PATHWAY

Reactome: R-HSA-900693646 genes255 compounds

The Signaling by TGFB family members pathway (Reactome ID: R-HSA-9006936) involves 46 genes and is affected by 255 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACVR1B ACVR2A ACVR2B ACVRL1 AGO2 APH1A APH1B ARRB1 BMPR1B CCNC CCNT2 CDK8 CDK9 EP300 FKBP1A FURIN HDAC1 ITGAV ITGB3 MAPK1 MAPK3 MEN1 MMP14 MYC NCOR1 NCOR2 NCSTN NEDD8 PARP1 PPP1CA+16 more

Compounds Affecting Signaling by TGFB family members

#	Compound	Targets Hit	Studies
1	Dasatinib	—	299
2	alsterpaullone	—	12
3	Dihydroergocristine	—	187
4	Hexachlorophene	—	300
5	Daunorubicin	—	298
6	Bortezomib	—	300
7	egcg	—	300
8	Sorafenib	—	300
9	cycloheximide	—	300
10	Astemizole Antihistamine drug now withdrawn from	—	280
11	Celecoxib	—	295
12	Dactinomycin	—	297
13	Danazol	—	298
14	Ethidium	—	300
15	Rotenone	—	300
16	Flutamide	—	298
17	Loratadine	—	296
18	Podophyllotoxin	—	14
19	kenpaullone	—	8
20	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
21	plumbagin [Supplementary Concept]	—	300
22	Disulfiram	—	297
23	Progesterone	—	299
24	Azacitidine	—	298
25	Azacitidine	—	300
26	Dinitrochlorobenzene	—	300
27	Promethazine	—	121
28	Vitamin	—	295
29	Clotrimazole	—	296
30	Nisoldipine	—	297
31	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
32	Methylene Blue	—	200
33	candesartan cilexetil [Supplementary Concept]	—	300
34	Colchicine	—	300
35	Emetine	—	298
36	Fluspirilene	—	74
37	Idazoxan	—	300
38	Lynestrenol	—	299
39	o-Phthalaldehyde	—	300
40	triflupromazine hydrochloride	—	12
41	Vincristine	—	299
42	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
43	chrysin	—	300
44	Fluoxetine	—	1,000
45	Kaempferols	—	300
46	Axitinib	—	298
47	Cladribine	—	297
48	Ethinyl Estradiol	—	300
49	Perphenazine	—	297
50	vinblastine sulfate	—	81

About the Signaling by TGFB family members Pathway

The Signaling by TGFB family members pathway is catalogued in Reactome (ID: R-HSA-9006936) and involves 46 genes. In the BiohacksAI corpus, 255 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACVR1B, ACVR2A, ACVR2B, ACVRL1, AGO2.