What compounds affect the Estrogen-dependent gene expression pathway?

430 compounds in the BiohacksAI corpus have documented interactions with genes in the Estrogen-dependent gene expression pathway (Reactome ID: R-HSA-9018519). These compounds target 26 genes within this pathway.

What genes are in the Estrogen-dependent gene expression pathway?

The Estrogen-dependent gene expression pathway involves 26 genes. Key genes include: AGO2, CARM1, CBFB, CDK9, CREBBP, EP300, ERBB4, ESR1, FKBP4, FOS.

Estrogen-dependent gene expression

REACTOME PATHWAY

Reactome: R-HSA-901851926 genes430 compounds

The Estrogen-dependent gene expression pathway (Reactome ID: R-HSA-9018519) involves 26 genes and is affected by 430 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AGO2 CARM1 CBFB CDK9 CREBBP EP300 ERBB4 ESR1 FKBP4 FOS HDAC1 HSP90AA1 HSP90AB1 JUN KAT2B KDM1A KDM4B MYC NCOA1 NCOA3 NR5A2 PGR POU2F1 PRMT1 PTGES3 RUNX1

Compounds Affecting Estrogen-dependent gene expression

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Ethidium	—	300
3	cycloheximide	—	300
4	Masoprocol	—	300
5	Quercetin	—	300
6	Daunorubicin	—	298
7	Methylene Blue	—	200
8	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
9	Digoxin	—	299
10	vinblastine sulfate	—	81
11	Clotrimazole	—	296
12	Nisoldipine	—	297
13	triolimus [Supplementary Concept]	—	33
14	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
15	Azacitidine	—	298
16	Azacitidine	—	300
17	Methotrexate	—	289
18	Danazol	—	298
19	Rotenone	—	300
20	Dihydrotestosterone	—	300
21	Ethynodiol Diacetate	—	300
22	Colchicine	—	300
23	Mestranol	—	300
24	Testosterone Propionate	—	300
25	Hexachlorophene	—	300
26	Lynestrenol	—	299
27	Phenoxybenzamine	—	21
28	Progesterone	—	299
29	Bortezomib	—	300
30	Triiodothyronine	—	300
31	Celecoxib	—	295
32	Ciclopirox	—	88
33	Toxaphene	—	299
34	Fenofibrate	—	297
35	Promethazine	—	121
36	Vincristine	—	299
37	Amoxapine	—	259
38	Dasatinib	—	299
39	Desoxycorticosterone	—	300
40	Stanozolol	—	300
41	Budesonide	—	1,000
42	Aurintricarboxylic Acid	—	184
43	Nitroprusside	—	299
44	Tetracycline	—	300
45	Idarubicin	—	299
46	egcg	—	300
47	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
48	gedunin	—	54
49	Anisomycin	—	247
50	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300

About the Estrogen-dependent gene expression Pathway

The Estrogen-dependent gene expression pathway is catalogued in Reactome (ID: R-HSA-9018519) and involves 26 genes. In the BiohacksAI corpus, 430 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AGO2, CARM1, CBFB, CDK9, CREBBP.