What compounds affect the SARS-CoV-1-host interactions pathway?

132 compounds in the BiohacksAI corpus have documented interactions with genes in the SARS-CoV-1-host interactions pathway (Reactome ID: R-HSA-9692914). These compounds target 22 genes within this pathway.

What genes are in the SARS-CoV-1-host interactions pathway?

The SARS-CoV-1-host interactions pathway involves 22 genes. Key genes include: BCL2L1, CASP1, EP300, FKBP1A, HNRNPA1, IKBKE, KPNB1, NFKB1, NFKBIA, NLRP3.

SARS-CoV-1-host interactions

REACTOME PATHWAY

Reactome: R-HSA-969291422 genes132 compounds

The SARS-CoV-1-host interactions pathway (Reactome ID: R-HSA-9692914) involves 22 genes and is affected by 132 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BCL2L1 CASP1 EP300 FKBP1A HNRNPA1 IKBKE KPNB1 NFKB1 NFKBIA NLRP3 NPM1 PDPK1 PKLR PSMC6 RELA RIPK3 RPSA RUNX1 SMAD3 TBK1 YWHAB YWHAG

Compounds Affecting SARS-CoV-1-host interactions

#	Compound	Targets Hit	Studies
1	Disulfiram	—	297
2	Quercetin	—	300
3	Bortezomib	—	300
4	egcg	—	300
5	Hexachlorophene	—	300
6	cycloheximide	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Kaempferols	—	300
9	Podophyllotoxin	—	14
10	vinblastine sulfate	—	81
11	Ethinyl Estradiol	—	300
12	Masoprocol	—	300
13	Crizotinib	—	298
14	alsterpaullone	—	12
15	Anisomycin	—	247
16	kenpaullone	—	8
17	Ethidium	—	300
18	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
19	Daunorubicin	—	298
20	Domperidone	—	299
21	Promethazine	—	121
22	streptonigrin	—	299
23	Resveratrol	—	298
24	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
25	Rutin	—	300
26	Withania	—	500
27	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
28	tamarixetin	—	26
29	Trifluridine	—	295
30	withaferin	—	300
31	plumbagin [Supplementary Concept]	—	300
32	chicoric acid	—	117
33	Thioridazine	—	35
34	Chlorhexidine	—	299
35	Aurintricarboxylic Acid	—	184
36	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
37	amlexanox	—	96
38	Calcimycin	—	216
39	Azacitidine	—	298
40	Azacitidine	—	300
41	Nisoldipine	—	297
42	Tubercidin	—	300
43	cardamonin	—	180
44	Colchicine	—	300
45	Dactinomycin	—	297
46	Danazol	—	298
47	Dasatinib	—	299
48	Dinitrochlorobenzene	—	300
49	Flutamide	—	298
50	Loratadine	—	296

About the SARS-CoV-1-host interactions Pathway

The SARS-CoV-1-host interactions pathway is catalogued in Reactome (ID: R-HSA-9692914) and involves 22 genes. In the BiohacksAI corpus, 132 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BCL2L1, CASP1, EP300, FKBP1A, HNRNPA1.