What genes are in the FLT3 signaling through SRC family kinases pathway?

The FLT3 signaling through SRC family kinases pathway involves 5 genes. Key genes include: FLT3, FYN, HCK, LCK, SYK.

FLT3 signaling through SRC family kinases

Q: What compounds affect the FLT3 signaling through SRC family kinases pathway?

209 compounds in the BiohacksAI corpus have documented interactions with genes in the FLT3 signaling through SRC family kinases pathway (Reactome ID: R-HSA-9706374). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-97063745 genes209 compounds

The FLT3 signaling through SRC family kinases pathway (Reactome ID: R-HSA-9706374) involves 5 genes and is affected by 209 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FLT3 FYN HCK LCK SYK

Compounds Affecting FLT3 signaling through SRC family kinases

#	Compound	Targets Hit	Studies
1	tyrphostin ag 1478	—	4
2	Sorafenib	—	300
3	Dasatinib	—	299
4	Crizotinib	—	298
5	Afatinib	—	297
6	kenpaullone	—	8
7	sp600125	—	117
8	Axitinib	—	298
9	piceatannol	—	300
10	pictilisib	—	25
11	Kaempferols	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Quercetin	—	300
14	Acetic Acid Product of	—	300
15	Ouabain	—	300
16	Atorvastatin	—	1,000
17	Simvastatin	—	1,000
18	Methotrexate	—	289
19	Chlorhexidine	—	299
20	Clofarabine	—	298
21	Colchicine	—	300
22	cycloheximide	—	300
23	deguelin [Supplementary Concept]	—	151
24	Digoxin	—	299
25	Disulfiram	—	297
26	Emetine	—	298
27	Ezetimibe	—	296
28	Lovastatin	—	300
29	Medroxyprogesterone Acetate	—	299
30	Melphalan	—	300
31	Mometasone Furoate	—	292
32	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
33	Niclosamide	—	299
34	Podophyllotoxin	—	14
35	Thapsigargin	—	300
36	torin 1	—	10
37	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
38	Trifluridine	—	295
39	fisetin	—	78
40	ag490	—	14
41	alpelisib	—	227
42	Azathioprine	—	300
43	Bortezomib	—	300
44	Maprotiline	—	299
45	Nocodazole Nocodazole is	—	215
46	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
47	Tripterygium	—	300
48	Vincristine	—	299
49	withaferin	—	300
50	Berberine	—	300

About the FLT3 signaling through SRC family kinases Pathway

The FLT3 signaling through SRC family kinases pathway is catalogued in Reactome (ID: R-HSA-9706374) and involves 5 genes. In the BiohacksAI corpus, 209 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FLT3, FYN, HCK, LCK, SYK.