What compounds affect the Drug ADME pathway?

693 compounds in the BiohacksAI corpus have documented interactions with genes in the Drug ADME pathway (Reactome ID: R-HSA-9748784). These compounds target 47 genes within this pathway.

What genes are in the Drug ADME pathway?

The Drug ADME pathway involves 47 genes. Key genes include: ABCB1, ABCC1, ABCC2, ABCC3, ABCC4, ABCC5, ABCG2, ADA, ADK, AKR1C1.

Drug ADME

REACTOME PATHWAY

Reactome: R-HSA-974878447 genes693 compounds

The Drug ADME pathway (Reactome ID: R-HSA-9748784) involves 47 genes and is affected by 693 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABCB1 ABCC1 ABCC2 ABCC3 ABCC4 ABCC5 ABCG2 ADA ADK AKR1C1 ALB BCHE CES1 CES2 CYP2C19 CYP2C8 CYP2C9 CYP2D6 CYP2E1 CYP3A4 GSTP1 HPRT1 HSD11B1 IMPDH1 IMPDH2 PNP PON1 SERPINA6 SLC22A1 SLC22A3+17 more

Compounds Affecting Drug ADME

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Delavirdine	—	296
3	Ritonavir	—	298
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Genistein	—	300
6	Kaempferols	—	300
7	Glyburide	—	298
8	Chlorhexidine	—	299
9	Progesterone	—	299
10	Simvastatin	—	1,000
11	Cefoperazone Semisynthetic broad-spectrum cephalosporin with	—	300
12	Ceftriaxone	—	299
13	Quinidine	—	298
14	Triiodothyronine	—	300
15	Clotrimazole	—	296
16	Ethinyl Estradiol	—	300
17	Flutamide	—	298
18	chrysin	—	300
19	Danazol	—	298
20	Gemfibrozil	—	297
21	Dihydrotestosterone	—	300
22	Mometasone Furoate	—	292
23	Reserpine	—	297
24	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
25	candesartan cilexetil [Supplementary Concept]	—	300
26	Thyroxine	—	994
27	Thyroxine	—	300
28	Dinoprostone	—	296
29	Disulfiram	—	297
30	Isoniazid Antibacterial agent used primarily as	—	299
31	Methoxsalen	—	300
32	Rotenone	—	300
33	Corticosterone	—	300
34	Loratadine	—	296
35	Vitamin K 3	—	300
36	Colchicine	—	300
37	Lovastatin	—	300
38	Nisoldipine	—	297
39	Phenylbutazone	—	300
40	Sulindac	—	297
41	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
42	Pueraria	—	300
43	Desoxycorticosterone	—	300
44	Hexachlorophene	—	300
45	Melphalan	—	300
46	Miconazole	—	298
47	Phenelzine	—	2
48	Budesonide	—	1,000
49	Troglitazone	—	299
50	cbd	—	298

About the Drug ADME Pathway

The Drug ADME pathway is catalogued in Reactome (ID: R-HSA-9748784) and involves 47 genes. In the BiohacksAI corpus, 693 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCB1, ABCC1, ABCC2, ABCC3, ABCC4.