What genes are in the Negative Regulation of CDH1 Gene Transcription pathway?

The Negative Regulation of CDH1 Gene Transcription pathway involves 12 genes. Key genes include: CTBP1, EED, EZH2, HDAC1, HDAC2, KDM1A, KMT5A, MAPK1, MAPK3, MPHOSPH8.

Negative Regulation of CDH1 Gene Transcription

Q: What compounds affect the Negative Regulation of CDH1 Gene Transcription pathway?

76 compounds in the BiohacksAI corpus have documented interactions with genes in the Negative Regulation of CDH1 Gene Transcription pathway (Reactome ID: R-HSA-9764725). These compounds target 12 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-976472512 genes76 compounds

The Negative Regulation of CDH1 Gene Transcription pathway (Reactome ID: R-HSA-9764725) involves 12 genes and is affected by 76 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CTBP1 EED EZH2 HDAC1 HDAC2 KDM1A KMT5A MAPK1 MAPK3 MPHOSPH8 PKM SIRT1

Compounds Affecting Negative Regulation of CDH1 Gene Transcription

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Quercetin	—	300
3	pd98059	—	7
4	Sorafenib	—	300
5	daph	—	2
6	trequinsin hydrochloride	—	1
7	plumbagin [Supplementary Concept]	—	300
8	alsterpaullone	—	12
9	kenpaullone	—	8
10	fisetin	—	78
11	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
12	trametinib	—	296
13	withaferin	—	300
14	Suramin	—	300
15	Vorinostat	—	299
16	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
17	scriptaid	—	53
18	Valproic Acid	—	296
19	pictilisib	—	25
20	Butyric Acid	—	300
21	Ursolic Acid	—	300
22	Celecoxib	—	295
23	Daunorubicin	—	298
24	Bortezomib	—	300
25	Camptothecin	—	300
26	Aurintricarboxylic Acid	—	184
27	Cisplatin	—	300
28	Nitroprusside	—	299
29	Methotrexate	—	289
30	Dequalinium	—	46
31	Diamide	—	300
32	Disulfiram	—	297
33	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
34	Fluspirilene	—	74
35	Idarubicin	—	299
36	Iodoacetamide	—	300
37	Levodopa	—	297
38	Methyldopa	—	297
39	Nicardipine	—	94
40	Perphenazine	—	297
41	piceatannol	—	300
42	Promethazine	—	121
43	Reserpine	—	297
44	Thioridazine	—	35
45	tyrphostin 9	—	2
46	tyrphostin ag 1478	—	4
47	Clotrimazole	—	296
48	sp600125	—	117
49	Progesterone	—	299
50	2-Chloroadenosine 2-Chloroadenosine.	—	300

About the Negative Regulation of CDH1 Gene Transcription Pathway

The Negative Regulation of CDH1 Gene Transcription pathway is catalogued in Reactome (ID: R-HSA-9764725) and involves 12 genes. In the BiohacksAI corpus, 76 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CTBP1, EED, EZH2, HDAC1, HDAC2.