What compounds affect the Amyloid fiber formation pathway?

68 compounds in the BiohacksAI corpus have documented interactions with genes in the Amyloid fiber formation pathway (Reactome ID: R-HSA-977225). These compounds target 12 genes within this pathway.

What genes are in the Amyloid fiber formation pathway?

The Amyloid fiber formation pathway involves 12 genes. Key genes include: ADAM10, APH1A, APH1B, APP, BACE1, FURIN, INS, NCSTN, PRKN, PSENEN.

Amyloid fiber formation

REACTOME PATHWAY

Reactome: R-HSA-97722512 genes68 compounds

The Amyloid fiber formation pathway (Reactome ID: R-HSA-977225) involves 12 genes and is affected by 68 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 APH1A APH1B APP BACE1 FURIN INS NCSTN PRKN PSENEN SNCA TTR

Compounds Affecting Amyloid fiber formation

#	Compound	Targets Hit	Studies
1	egcg	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Dihydroergocristine	—	187
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Vitamin	—	295
7	Catechin	—	300
8	Genistein	—	300
9	Resveratrol	—	298
10	Quercetin	—	300
11	Hesperidin	—	300
12	Kaempferols	—	300
13	(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses	—	300
14	Digitoxin	—	300
15	Digoxin	—	299
16	Vanillic Acid	—	300
17	Retinaldehyde	—	300
18	Masoprocol	—	300
19	Rosmarinic Acid	—	300
20	Hexachlorophene	—	300
21	Methylene Blue	—	200
22	caffeic acid	—	300
23	2-Methoxyestradiol	—	300
24	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
25	Cladribine	—	297
26	Disulfiram	—	297
27	Edetic Acid	—	24
28	Ouabain	—	300
29	Podophyllotoxin	—	14
30	Quinic Acid	—	218
31	streptonigrin	—	299
32	Trifluridine	—	295
33	Bortezomib	—	300
34	Calcimycin	—	216
35	celastrol	—	300
36	Hydroxyurea	—	300
37	Niacin	—	295
38	Azauridine	—	300
39	Ceftriaxone	—	299
40	ketoconazole	—	299
41	Lithocholic Acid	—	300
42	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
43	Pergolide	—	299
44	Pramipexole	—	297
45	Tetracycline	—	300
46	Niflumic Acid	—	300
47	Thyroxine	—	994
48	pterostilbene	—	299
49	piceatannol	—	300
50	Thyroxine	—	300

About the Amyloid fiber formation Pathway

The Amyloid fiber formation pathway is catalogued in Reactome (ID: R-HSA-977225) and involves 12 genes. In the BiohacksAI corpus, 68 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, APH1A, APH1B, APP, BACE1.