What compounds target ADRA2B?

BiohacksAI has identified 74 compounds that interact with ADRA2B (adrenoceptor alpha 2B). Top compounds include: Yohimbine, Clonidine, Idazoxan, Oxymetazoline, Phentolamine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ADRA2B (adrenoceptor alpha 2B)?

ADRA2B is adrenoceptor alpha 2B. It is a molecular target for 74 compounds documented in PubMed bioassay data. UniProt ID: P18089. NCBI Gene ID: 151.

ADRA2B

MOLECULAR TARGET

adrenoceptor alpha 2B

UniProt: P18089 NCBI Gene: 15174 compounds

ADRA2B (adrenoceptor alpha 2B) is targeted by 74 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ADRA2B

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Yohimbine	4.37	78
2	Clonidine	3.50	32
3	Idazoxan	3.50	32
4	Oxymetazoline	3.50	32
5	Phentolamine	3.37	28
6	Norepinephrine Precursor of epinephrine that is secreted by	3.14	22
7	Epinephrine	2.64	13
8	Mianserin	2.20	8
9	Phenylephrine	2.08	7
10	Piperoxan	2.08	7
11	Dexmedetomidine	1.79	5
12	Rilmenidine Oxazole derivative that acts as	1.79	5
13	Tolazoline	1.79	5
14	Quetiapine Fumarate	1.61	4
15	Naphazoline	1.61	4
16	Pergolide	1.61	4
17	Fluoxetine	1.39	3
18	Bromocriptine	1.39	3
19	Carvedilol	1.39	3
20	Dihydroergotamine	1.39	3
21	Tamsulosin	1.39	3
22	Amisulpride	1.10	2
23	Aripiprazole	1.10	2
24	Cabergoline	1.10	2
25	Dihydroergotamine	1.10	2
26	Guanfacine	1.10	2
27	Lisuride	1.10	2
28	Phenoxybenzamine	1.10	2
29	cbd	0.69	1
30	Duloxetine Hydrochloride	0.69	1
31	Sertraline	0.69	1
32	vinpocetine	0.69	1
33	Ascorbic Acid	0.69	1
34	Afatinib	0.69	1
35	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	0.69	1
36	Amoxapine	0.69	1
37	Ascorbic Acid	0.69	1
38	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
39	Buspirone	0.69	1
40	cannabidiol	0.69	1
41	Cefepime	0.69	1
42	Celecoxib	0.69	1
43	Chlorhexidine	0.69	1
44	Chlorpheniramine	0.69	1
45	Dihydroergocornine	0.69	1
46	Domperidone	0.69	1
47	Ergotamine	0.69	1
48	Fentanyl	0.69	1
49	Fluspirilene	0.69	1
50	Guanabenz	0.69	1

Showing top 50 of 74 compounds. Use the BiohacksAI search to explore all ADRA2B modulators.

About ADRA2B as a Drug Target

ADRA2B (adrenoceptor alpha 2B) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 74 compounds with documented ADRA2B interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ADRA2B inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.