Question 1

What compounds target ALPHA-1D?

Accepted Answer

BiohacksAI has identified 36 compounds that interact with ALPHA-1D (Alpha-1D adrenergic receptor (human)). Top compounds include: Clonidine, Yohimbine, Mianserin, Quetiapine Fumarate, Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is ALPHA-1D (Alpha-1D adrenergic receptor)?

Accepted Answer

ALPHA-1D is Alpha-1D adrenergic receptor (human). It is a molecular target for 36 compounds documented in PubMed bioassay data. UniProt ID: P25100.

#	Compound	Confidence	Active Assays
1	Clonidine	1.39	3
2	Yohimbine	1.39	3
3	Mianserin	1.10	2
4	Quetiapine Fumarate	1.10	2
5	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.10	2
6	Amoxapine	1.10	2
7	Astemizole Antihistamine drug now withdrawn from	1.10	2
8	Hyoscyamine	1.10	2
9	Bromocriptine	1.10	2
10	Buspirone	1.10	2
11	Carvedilol	1.10	2
12	Cinnarizine	1.10	2
13	Cyclizine	1.10	2
14	Cyproheptadine	1.10	2
15	Dihydroergotamine	1.10	2
16	Dimenhydrinate	1.10	2
17	Domperidone	1.10	2
18	Econazole	1.10	2
19	Epinephrine	1.10	2
20	Ergotamine	1.10	2
21	Flunarizine Flunarizine is	1.10	2
22	Guanabenz	1.10	2
23	Labetalol	1.10	2
24	Lisuride	1.10	2
25	Maprotiline	1.10	2
26	Metergoline	1.10	2
27	Miconazole	1.10	2
28	Nortriptyline	1.10	2
29	Oxymetazoline	1.10	2
30	Pergolide	1.10	2
31	Phentolamine	1.10	2
32	Promethazine	1.10	2
33	Trazodone	1.10	2
34	Clotrimazole	0.69	1
35	Dexmedetomidine	0.69	1
36	Norepinephrine Precursor of epinephrine that is secreted by	0.69	1

BiohacksAI

ALPHA-1D

Compounds Targeting ALPHA-1D

About ALPHA-1D as a Drug Target