What compounds target DRD1?

BiohacksAI has identified 106 compounds that interact with DRD1 (dopamine receptor D1). Top compounds include: Aripiprazole, Pergolide, SCH 23390 [Supplementary Concept], Quetiapine Fumarate, Bromocriptine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DRD1 (dopamine receptor D1)?

DRD1 is dopamine receptor D1. It is a molecular target for 106 compounds documented in PubMed bioassay data. UniProt ID: P21728. NCBI Gene ID: 1812.

DRD1

MOLECULAR TARGET

dopamine receptor D1

UniProt: P21728 NCBI Gene: 1812106 compounds

DRD1 (dopamine receptor D1) is targeted by 106 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DRD1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Aripiprazole	2.77	15
2	Pergolide	2.64	13
3	SCH 23390 [Supplementary Concept]	2.48	11
4	Quetiapine Fumarate	2.20	8
5	Bromocriptine	2.08	7
6	skf83959	1.95	6
7	Butaclamol	1.79	5
8	Cabergoline	1.79	5
9	Carvedilol	1.79	5
10	Metergoline	1.79	5
11	Norepinephrine Precursor of epinephrine that is secreted by	1.79	5
12	Mianserin	1.61	4
13	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.61	4
14	Dihydroergotamine	1.61	4
15	Epinephrine	1.61	4
16	Lisuride	1.61	4
17	Yohimbine	1.61	4
18	Fluoxetine	1.39	3
19	Sertraline	1.39	3
20	Amoxapine	1.39	3
21	Calcimycin	1.39	3
22	Cyproheptadine	1.39	3
23	Hexachlorophene	1.39	3
24	Loxapine	1.39	3
25	Maprotiline	1.39	3
26	Methylergonovine	1.39	3
27	Promethazine	1.39	3
28	Raclopride	1.39	3
29	cbd	1.10	2
30	Astemizole Antihistamine drug now withdrawn from	1.10	2
31	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
32	cannabidiol	1.10	2
33	Dihydroergocristine	1.10	2
34	Idarubicin	1.10	2
35	Indoramin	1.10	2
36	Loxapine	1.10	2
37	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.10	2
38	Methysergide	1.10	2
39	Nortriptyline	1.10	2
40	Perphenazine	1.10	2
41	Phenylephrine	1.10	2
42	pirenperone	1.10	2
43	Promazine	1.10	2
44	Thioridazine	1.10	2
45	triflupromazine hydrochloride	1.10	2
46	Duloxetine Hydrochloride	0.69	1
47	Quercetin	0.69	1
48	Simvastatin	0.69	1
49	vinpocetine	0.69	1
50	20-alpha-Dihydroprogesterone	0.69	1

Showing top 50 of 106 compounds. Use the BiohacksAI search to explore all DRD1 modulators.

About DRD1 as a Drug Target

DRD1 (dopamine receptor D1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 106 compounds with documented DRD1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DRD1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.