Question 1

What compounds target HTR2C?

Accepted Answer

BiohacksAI has identified 61 compounds that interact with HTR2C (5-hydroxytryptamine receptor 2C). Top compounds include: Aripiprazole, Mianserin, Quipazine, Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is, Buspirone. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

Question 2

What is HTR2C (5-hydroxytryptamine receptor 2C)?

Accepted Answer

HTR2C is 5-hydroxytryptamine receptor 2C. It is a molecular target for 61 compounds documented in PubMed bioassay data. UniProt ID: P28335. NCBI Gene ID: 3358.

#	Compound	Confidence	Active Assays
1	Aripiprazole	3.04	20
2	Mianserin	3.00	19
3	Quipazine	2.89	17
4	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	2.40	10
5	Buspirone	2.20	8
6	Lisuride	2.20	8
7	Mescaline Hallucinogenic alkaloid isolated from	2.08	7
8	Methysergide	2.08	7
9	Quetiapine Fumarate	1.95	6
10	Metergoline	1.95	6
11	Pergolide	1.95	6
12	Ergotamine	1.79	5
13	Methylergonovine	1.79	5
14	Fluoxetine	1.61	4
15	Cyproheptadine	1.61	4
16	Loxapine	1.61	4
17	Trazodone	1.61	4
18	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.39	3
19	Bromocriptine	1.39	3
20	Oxymetazoline	1.39	3
21	pirenperone	1.39	3
22	Losartan	1.10	2
23	Amoxapine	1.10	2
24	brl 15572	1.10	2
25	Bufotenin	1.10	2
26	Cabergoline	1.10	2
27	Dihydroergotamine	1.10	2
28	Nortriptyline	1.10	2
29	Ondansetron	1.10	2
30	Perphenazine	1.10	2
31	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	1.10	2
32	Platelet Activating Factor	1.10	2
33	Sumatriptan	1.10	2
34	cbd	0.69	1
35	Duloxetine Hydrochloride	0.69	1
36	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	0.69	1
37	Psilocybin	0.69	1
38	Sertraline	0.69	1
39	Aprindine	0.69	1
40	Astemizole Antihistamine drug now withdrawn from	0.69	1
41	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	0.69	1
42	cannabidiol	0.69	1
43	Carvedilol	0.69	1
44	Cefpodoxime	0.69	1
45	Chlorhexidine	0.69	1
46	cinacalcet	0.69	1
47	Dihydroergocornine	0.69	1
48	Dihydroergotamine	0.69	1
49	Encainide	0.69	1
50	Guanfacine	0.69	1

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HTR2C

Compounds Targeting HTR2C

About HTR2C as a Drug Target