What compounds target SLC6A4?

BiohacksAI has identified 67 compounds that interact with SLC6A4 (solute carrier family 6 member 4). Top compounds include: Fluoxetine, Venlafaxine Hydrochloride, Sertraline, Vortioxetine, Duloxetine Hydrochloride. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SLC6A4 (solute carrier family)?

SLC6A4 is solute carrier family 6 member 4. It is a molecular target for 67 compounds documented in PubMed bioassay data. UniProt ID: P31645. NCBI Gene ID: 6532.

SLC6A4

MOLECULAR TARGET

solute carrier family 6 member 4

UniProt: P31645 NCBI Gene: 653267 compounds

SLC6A4 (solute carrier family 6 member 4) is targeted by 67 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SLC6A4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Fluoxetine	3.50	32
2	Venlafaxine Hydrochloride	2.40	10
3	Sertraline	1.95	6
4	Vortioxetine	1.79	5
5	Duloxetine Hydrochloride	1.61	4
6	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	1.61	4
7	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.61	4
8	Fluvoxamine	1.61	4
9	Quipazine	1.61	4
10	Aripiprazole	1.39	3
11	Amoxapine	1.10	2
12	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
13	Ethinyl Estradiol	1.10	2
14	Meperidine	1.10	2
15	Metergoline	1.10	2
16	Nortriptyline	1.10	2
17	Promethazine	1.10	2
18	Mianserin	0.69	1
19	vinpocetine	0.69	1
20	Aprindine	0.69	1
21	Astemizole Antihistamine drug now withdrawn from	0.69	1
22	Benzydamine	0.69	1
23	Carvedilol	0.69	1
24	Celecoxib	0.69	1
25	Cetirizine	0.69	1
26	Chlorhexidine	0.69	1
27	Chlorpheniramine	0.69	1
28	cinacalcet	0.69	1
29	Cinnarizine	0.69	1
30	Clotrimazole	0.69	1
31	Crizotinib	0.69	1
32	Cyproheptadine	0.69	1
33	Dequalinium	0.69	1
34	Desogestrel	0.69	1
35	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	0.69	1
36	dilazep	0.69	1
37	Econazole	0.69	1
38	Estrone	0.69	1
39	Fenoterol	0.69	1
40	Flunarizine Flunarizine is	0.69	1
41	Fluspirilene	0.69	1
42	Gestrinone	0.69	1
43	hydroxyfasudil [Supplementary Concept]	0.69	1
44	Idarubicin	0.69	1
45	Levorphanol	0.69	1
46	lidoflazine	0.69	1
47	Loxapine	0.69	1
48	Mestranol	0.69	1
49	Nebivolol	0.69	1
50	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	0.69	1

Showing top 50 of 67 compounds. Use the BiohacksAI search to explore all SLC6A4 modulators.

About SLC6A4 as a Drug Target

SLC6A4 (solute carrier family 6 member 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 67 compounds with documented SLC6A4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SLC6A4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.