What compounds affect the Neurotransmitter clearance pathway?

193 compounds in the BiohacksAI corpus have documented interactions with genes in the Neurotransmitter clearance pathway (Reactome ID: R-HSA-112311). These compounds target 7 genes within this pathway.

What genes are in the Neurotransmitter clearance pathway?

The Neurotransmitter clearance pathway involves 7 genes. Key genes include: ACHE, ALDH2, BCHE, MAOA, SLC22A1, SLC6A3, SLC6A4.

Neurotransmitter clearance

REACTOME PATHWAY

Reactome: R-HSA-1123117 genes193 compounds

The Neurotransmitter clearance pathway (Reactome ID: R-HSA-112311) involves 7 genes and is affected by 193 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ACHE ALDH2 BCHE MAOA SLC22A1 SLC6A3 SLC6A4

Compounds Affecting Neurotransmitter clearance

#	Compound	Targets Hit	Studies
1	Aripiprazole	—	298
2	Chlorhexidine	—	299
3	pentamidine	—	299
4	Quinidine	—	298
5	Fluoxetine	—	1,000
6	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
7	Astemizole Antihistamine drug now withdrawn from	—	280
8	Carvedilol	—	296
9	Dequalinium	—	136
10	Metergoline	—	144
11	Phenelzine	—	297
12	ethopropazine	—	17
13	Duloxetine Hydrochloride	—	993
14	Sertraline	—	1,000
15	Venlafaxine Hydrochloride	—	1,000
16	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
17	Cabergoline	—	299
18	Ethinyl Estradiol	—	300
19	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	—	995
20	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
21	Amoxapine	—	259
22	Benzydamine	—	298
23	Celecoxib	—	295
24	Cetirizine	—	296
25	Chlorpheniramine	—	298
26	cinacalcet	—	298
27	Cinnarizine	—	299
28	Crizotinib	—	298
29	Estrone	—	300
30	Flunarizine Flunarizine is	—	299
31	Fluspirilene	—	74
32	Fluvoxamine	—	297
33	Hexachlorophene	—	300
34	lidoflazine	—	278
35	Nebivolol	—	297
36	Nefopam Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for	—	299
37	Nortriptyline	—	295
38	oxatomide [Supplementary Concept] structure;	—	128
39	Oxyfedrine	—	144
40	Perphenazine	—	297
41	Sorafenib	—	300
42	Thiethylperazine	—	165
43	Physostigmine	—	300
44	Physostigmine	—	299
45	Methylene Blue	—	200
46	Nicergoline	—	300
47	Berberine	—	300
48	Progesterone	—	299
49	Procainamide	—	297
50	Apigenin 5,7,4'-trihydroxy-flavone,	—	300

About the Neurotransmitter clearance Pathway

The Neurotransmitter clearance pathway is catalogued in Reactome (ID: R-HSA-112311) and involves 7 genes. In the BiohacksAI corpus, 193 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ACHE, ALDH2, BCHE, MAOA, SLC22A1.