What compounds target SLC6A3?

BiohacksAI has identified 70 compounds that interact with SLC6A3 (solute carrier family 6 member 3). Top compounds include: Duloxetine Hydrochloride, Fluoxetine, Modafinil, Sertraline, Venlafaxine Hydrochloride. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is SLC6A3 (solute carrier family)?

SLC6A3 is solute carrier family 6 member 3. It is a molecular target for 70 compounds documented in PubMed bioassay data. UniProt ID: Q01959. NCBI Gene ID: 6531.

SLC6A3

MOLECULAR TARGET

solute carrier family 6 member 3

UniProt: Q01959 NCBI Gene: 653170 compounds

SLC6A3 (solute carrier family 6 member 3) is targeted by 70 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting SLC6A3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Duloxetine Hydrochloride	3.00	19
2	Fluoxetine	2.94	18
3	Modafinil	2.94	18
4	Sertraline	2.20	8
5	Venlafaxine Hydrochloride	2.20	8
6	Digoxin	1.39	3
7	Ouabain	1.39	3
8	Ticagrelor	1.39	3
9	Amlodipine	1.10	2
10	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	1.10	2
11	Aripiprazole	1.10	2
12	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	1.10	2
13	Cabergoline	1.10	2
14	Ethinyl Estradiol	1.10	2
15	Ibogaine	1.10	2
16	streptonigrin	1.10	2
17	Escitalopram S-enantiomer of CITALOPRAM. Belongs to	0.69	1
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
19	Simvastatin	0.69	1
20	Amoxapine	0.69	1
21	Antazoline	0.69	1
22	Astemizole Antihistamine drug now withdrawn from	0.69	1
23	Axitinib	0.69	1
24	Benzydamine	0.69	1
25	Calcitriol	0.69	1
26	Canagliflozin	0.69	1
27	Carvedilol	0.69	1
28	Caspofungin	0.69	1
29	Celecoxib	0.69	1
30	Cetirizine	0.69	1
31	Chlorhexidine	0.69	1
32	Chlorpheniramine	0.69	1
33	cinacalcet	0.69	1
34	Cinnarizine	0.69	1
35	Crizotinib	0.69	1
36	Cyclizine	0.69	1
37	Dequalinium	0.69	1
38	Digitoxin	0.69	1
39	Domperidone	0.69	1
40	Estrone	0.69	1
41	Flunarizine Flunarizine is	0.69	1
42	Fluspirilene	0.69	1
43	Fluvoxamine	0.69	1
44	Hexachlorophene	0.69	1
45	Indomethacin	0.69	1
46	Labetalol	0.69	1
47	Leflunomide	0.69	1
48	lidoflazine	0.69	1
49	Loratadine	0.69	1
50	Maprotiline	0.69	1

Showing top 50 of 70 compounds. Use the BiohacksAI search to explore all SLC6A3 modulators.

About SLC6A3 as a Drug Target

SLC6A3 (solute carrier family 6 member 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 70 compounds with documented SLC6A3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

SLC6A3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.