What compounds affect the MTOR signalling pathway?

51 compounds in the BiohacksAI corpus have documented interactions with genes in the MTOR signalling pathway (Reactome ID: R-HSA-165159). These compounds target 14 genes within this pathway.

What genes are in the MTOR signalling pathway?

The MTOR signalling pathway involves 14 genes. Key genes include: EIF4G1, FKBP1A, MLST8, MTOR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2.

MTOR signalling

REACTOME PATHWAY

Reactome: R-HSA-16515914 genes51 compounds

The MTOR signalling pathway (Reactome ID: R-HSA-165159) involves 14 genes and is affected by 51 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EIF4G1 FKBP1A MLST8 MTOR PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG1 PRKAG2 PRKAG3 RPS6KB1 RPTOR YWHAB

Compounds Affecting MTOR signalling

#	Compound	Targets Hit	Studies
1	Rotenone	—	300
2	Niclosamide	—	299
3	Ursolic Acid	—	300
4	Adenosine Monophosphate Adenine nucleotide containing	—	300
5	Proguanil	—	299
6	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	—	76
7	Berberine	—	300
8	Antimycin	—	300
9	Oleanolic Acid	—	300
10	Metformin	—	1,000
11	Sirolimus	—	300
12	Everolimus	—	297
13	torin 1	—	10
14	Ku 0063794 [Supplementary Concept]	—	7
15	Quercetin	—	300
16	Crizotinib	—	298
17	pictilisib	—	25
18	ly294002	—	11
19	Thapsigargin	—	300
20	Wortmannin	—	300
21	alpelisib	—	227
22	amn082	—	29
23	Calcimycin	—	216
24	Idarubicin	—	299
25	Idazoxan	—	300
26	triolimus [Supplementary Concept]	—	33
27	tyrphostin 9	—	2
28	egcg	—	300
29	Camptothecin	—	300
30	Dequalinium	—	136
31	Disulfiram	—	297
32	Emetine	—	298
33	Epinephrine	—	299
34	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
35	Maprotiline	—	299
36	Perphenazine	—	297
37	Kaempferols	—	300
38	Rutin	—	300
39	DEAD-box RNA Helicases	—	169
40	Thioctic Acid	—	298
41	Hexachlorophene	—	300
42	Thioctic Acid	—	300
43	Azauridine	—	300
44	Levetiracetam	—	296
45	Oxytetracycline	—	300
46	hydroxyfasudil [Supplementary Concept]	—	11
47	alsterpaullone	—	12
48	Sorafenib	—	300
49	sp600125	—	117
50	cycloheximide	—	300

About the MTOR signalling Pathway

The MTOR signalling pathway is catalogued in Reactome (ID: R-HSA-165159) and involves 14 genes. In the BiohacksAI corpus, 51 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF4G1, FKBP1A, MLST8, MTOR, PRKAA1.