Influenza Viral RNA Transcription and Replication

Q: What compounds affect the Influenza Viral RNA Transcription and Replication pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Influenza Viral RNA Transcription and Replication pathway (Reactome ID: R-HSA-168273). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1682733 genes47 compounds

The Influenza Viral RNA Transcription and Replication pathway (Reactome ID: R-HSA-168273) involves 3 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

HSP90AA1 PARP1 RPSA

Compounds Affecting Influenza Viral RNA Transcription and Replication

#	Compound	Targets Hit	Studies
1	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
2	triolimus [Supplementary Concept]	—	33
3	monorden	—	8
4	gedunin	—	54
5	celastrol	—	300
6	Novobiocin	—	300
7	caffeic acid	—	300
8	Masoprocol	—	300
9	Tetracycline	—	300
10	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
11	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
12	Quercetin	—	300
13	2-Chloroadenosine 2-Chloroadenosine.	—	300
14	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
15	ag490	—	14
16	Calcimycin	—	216
17	Calcitriol	—	300
18	Ciclopirox	—	88
19	Clotrimazole	—	296
20	cycloheximide	—	300
21	deguelin [Supplementary Concept]	—	151
22	Disulfiram	—	297
23	Hexachlorophene	—	300
24	Idarubicin	—	299
25	Indazoles	—	300
26	Miconazole	—	298
27	piceatannol	—	300
28	Nitroprusside	—	299
29	specioside	—	6
30	Wortmannin	—	300
31	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
32	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
33	Bortezomib	—	300
34	Camptothecin	—	300
35	Clofarabine	—	298
36	Daunorubicin	—	298
37	Demecolcine	—	246
38	Epirubicin	—	300
39	Gemcitabine	—	300
40	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
41	Irinotecan	—	298
42	Nocodazole Nocodazole is	—	215
43	Podophyllotoxin	—	14
44	Teniposide	—	299
45	Thapsigargin	—	300
46	Trabectedin	—	297
47	egcg	—	300

About the Influenza Viral RNA Transcription and Replication Pathway

The Influenza Viral RNA Transcription and Replication pathway is catalogued in Reactome (ID: R-HSA-168273) and involves 3 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HSP90AA1, PARP1, RPSA.