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BiohacksAI

Evidence-Based Biohacking

Patent Pending

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

REACTOME PATHWAY
Reactome: R-HSA-16864326 genes130 compounds

The Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway (Reactome ID: R-HSA-168643) involves 26 genes and is affected by 130 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APPBCL2L1CASP1CASP2CASP4CASP9CHUKHSP90AB1IKBKBIRAK1MAP3K7MAPK11MAPK12MAPK13MAPK14NFKB1NFKB2NLRP1NLRP3NOD1NOD2P2RX7PANX1RELARIPK2UBE2N

Compounds Affecting Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

#CompoundTargets HitStudies
1isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from—300
2withaferin—300
3Anisomycin—247
4Sorafenib—300
5Quercetin—300
6Disulfiram—297
7Resveratrol—298
8Hexachlorophene—300
9Bortezomib—300
10Apigenin 5,7,4'-trihydroxy-flavone,—300
11Kaempferols—300
12Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
13Thioridazine—35
14Afatinib—297
15Crizotinib—298
16Podophyllotoxin—14
17egcg—300
18Rutin—300
19Withania—500
20tamarixetin—26
21Trifluridine—295
22myricetin-3-O-galactopyranoside [Supplementary Concept]—300
23Digitoxin—300
24Digoxin—299
25Ouabain—300
26chicoric acid—117
27cycloheximide—300
28Ethinyl Estradiol—300
29Dasatinib—299
30streptonigrin—299
31tyrphostin ag 1478—4
32Methylene Blue—200
33caffeic acid—300
34vinblastine sulfate—81
35Calcitriol—300
36Chlorhexidine—299
37Masoprocol—300
38Tetracycline—300
39Camptothecin—300
40Aurintricarboxylic Acid—184
41Norethynodrel—299
42Oxyphenbutazone—300
43Axitinib—298
44Adenosine Triphosphate—300
45alsterpaullone—12
46sp600125—117
47felbinac—31
48Hydrocortisone—299
49Cerulenin—300
50Chlorpropamide—300

About the Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Pathway

The Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway is catalogued in Reactome (ID: R-HSA-168643) and involves 26 genes. In the BiohacksAI corpus, 130 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, BCL2L1, CASP1, CASP2, CASP4.