What genes are in the Regulation of PLK1 Activity at G2/M Transition pathway?

The Regulation of PLK1 Activity at G2/M Transition pathway involves 18 genes. Key genes include: AURKA, CCNB1, CCNB2, CDK1, CSNK1D, CSNK1E, CUL1, HSP90AA1, NEK2, PLK1.

Regulation of PLK1 Activity at G2/M Transition

Q: What compounds affect the Regulation of PLK1 Activity at G2/M Transition pathway?

76 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of PLK1 Activity at G2/M Transition pathway (Reactome ID: R-HSA-2565942). These compounds target 18 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-256594218 genes76 compounds

The Regulation of PLK1 Activity at G2/M Transition pathway (Reactome ID: R-HSA-2565942) involves 18 genes and is affected by 76 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKA CCNB1 CCNB2 CDK1 CSNK1D CSNK1E CUL1 HSP90AA1 NEK2 PLK1 PLK4 PRKACA TUBA1A TUBA4A TUBB TUBB4A TUBB4B YWHAG

Compounds Affecting Regulation of PLK1 Activity at G2/M Transition

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	kenpaullone	—	8
3	alsterpaullone	—	12
4	Colchicine	—	300
5	Nocodazole Nocodazole is	—	215
6	Podophyllotoxin	—	14
7	Vincristine	—	299
8	Demecolcine	—	246
9	Maytansine	—	300
10	Noscapine	—	300
11	vinblastine sulfate	—	81
12	Vorinostat	—	299
13	Quercetin	—	300
14	indirubin	—	300
15	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
16	chrysin	—	300
17	fisetin	—	78
18	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
19	Sorafenib	—	300
20	pictilisib	—	25
21	Masoprocol	—	300
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	Clotrimazole	—	296
24	Disulfiram	—	297
25	Hexachlorophene	—	300
26	Idarubicin	—	299
27	Wortmannin	—	300
28	Axitinib	—	298
29	Crizotinib	—	298
30	Dasatinib	—	299
31	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
32	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
33	triolimus [Supplementary Concept]	—	33
34	monorden	—	8
35	gedunin	—	54
36	celastrol	—	300
37	Novobiocin	—	300
38	caffeic acid	—	300
39	Tetracycline	—	300
40	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
41	2-Chloroadenosine 2-Chloroadenosine.	—	300
42	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
43	ag490	—	14
44	Calcimycin	—	216
45	Calcitriol	—	300
46	Ciclopirox	—	88
47	cycloheximide	—	300
48	deguelin [Supplementary Concept]	—	151
49	Indazoles	—	300
50	Miconazole	—	298

About the Regulation of PLK1 Activity at G2/M Transition Pathway

The Regulation of PLK1 Activity at G2/M Transition pathway is catalogued in Reactome (ID: R-HSA-2565942) and involves 18 genes. In the BiohacksAI corpus, 76 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKA, CCNB1, CCNB2, CDK1, CSNK1D.