What compounds affect the EPH-Ephrin signaling pathway?

58 compounds in the BiohacksAI corpus have documented interactions with genes in the EPH-Ephrin signaling pathway (Reactome ID: R-HSA-2682334). These compounds target 31 genes within this pathway.

What genes are in the EPH-Ephrin signaling pathway?

The EPH-Ephrin signaling pathway involves 31 genes. Key genes include: ADAM10, APH1A, APH1B, CDC42, CFL1, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5.

EPH-Ephrin signaling

REACTOME PATHWAY

Reactome: R-HSA-268233431 genes58 compounds

The EPH-Ephrin signaling pathway (Reactome ID: R-HSA-2682334) involves 31 genes and is affected by 58 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADAM10 APH1A APH1B CDC42 CFL1 EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 EPHB2 EPHB3 EPHB4 EPHB6 FYN GRIN1 GRIN2B LIMK1 LIMK2 LYN NCSTN PSEN1 PSEN2 PSENEN ROCK2 SRC+1 more

Compounds Affecting EPH-Ephrin signaling

#	Compound	Targets Hit	Studies
1	Crizotinib	—	298
2	Sorafenib	—	300
3	Dasatinib	—	299
4	Dihydroergocristine	—	187
5	tyrphostin ag 1478	—	4
6	kenpaullone	—	8
7	Afatinib	—	297
8	alsterpaullone	—	12
9	sp600125	—	117
10	Glutamic Acid	—	297
11	Glutamic Acid	—	300
12	Glycine	—	300
13	pentamidine	—	299
14	Dextromethorphan Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of	—	296
15	Dextrorphan Dextro form of levorphanol. It acts as	—	300
16	Levorphanol	—	297
17	cycloserine	—	298
18	Aspartic Acid	—	300
19	eliprodil	—	33
20	Memantine AMANTADINE derivative that has some dopaminergic effects. It has been proposed as	—	34
21	D-Aspartic Acid	—	29
22	Ethidium	—	300
23	Dextrothyroxine	—	134
24	Dizocilpine Maleate	—	300
25	Ibotenic Acid	—	300
26	Spermine	—	300
27	Quercetin	—	300
28	Axitinib	—	298
29	Kaempferols	—	300
30	pictilisib	—	25
31	Kynurenic Acid	—	300
32	Phenformin	—	300
33	Carvedilol	—	296
34	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
35	Cladribine	—	297
36	Pioglitazone	—	297
37	Vemurafenib	—	298
38	Resveratrol	—	298
39	Adenosine Monophosphate Adenine nucleotide containing	—	300
40	monorden	—	8
41	Niclosamide	—	299
42	Rosmarinic Acid	—	300
43	Genistein	—	300
44	egcg	—	300
45	Acetic Acid Product of	—	300
46	hydroxyfasudil [Supplementary Concept]	—	11
47	Kinetin	—	300
48	Edaravone	—	298
49	Sertraline	—	1,000
50	Cinnarizine	—	299

About the EPH-Ephrin signaling Pathway

The EPH-Ephrin signaling pathway is catalogued in Reactome (ID: R-HSA-2682334) and involves 31 genes. In the BiohacksAI corpus, 58 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, APH1A, APH1B, CDC42, CFL1.