What genes are in the Role of LAT2/NTAL/LAB on calcium mobilization pathway?

The Role of LAT2/NTAL/LAB on calcium mobilization pathway involves 8 genes. Key genes include: FYN, GRB2, LYN, PDPK1, PIK3CB, PIK3R1, PIK3R2, SYK.

Role of LAT2/NTAL/LAB on calcium mobilization

Q: What compounds affect the Role of LAT2/NTAL/LAB on calcium mobilization pathway?

209 compounds in the BiohacksAI corpus have documented interactions with genes in the Role of LAT2/NTAL/LAB on calcium mobilization pathway (Reactome ID: R-HSA-2730905). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-27309058 genes209 compounds

The Role of LAT2/NTAL/LAB on calcium mobilization pathway (Reactome ID: R-HSA-2730905) involves 8 genes and is affected by 209 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYN GRB2 LYN PDPK1 PIK3CB PIK3R1 PIK3R2 SYK

Compounds Affecting Role of LAT2/NTAL/LAB on calcium mobilization

#	Compound	Targets Hit	Studies
1	ly294002	—	11
2	pictilisib	—	25
3	kenpaullone	—	8
4	Dasatinib	—	299
5	Crizotinib	—	298
6	sp600125	—	117
7	tyrphostin ag 1478	—	4
8	alpelisib	—	227
9	Sorafenib	—	300
10	alsterpaullone	—	12
11	Sirolimus	—	300
12	torin 1	—	10
13	Quercetin	—	300
14	Wortmannin	—	300
15	Ouabain	—	300
16	Atorvastatin	—	1,000
17	Simvastatin	—	1,000
18	Methotrexate	—	289
19	Chlorhexidine	—	299
20	Clofarabine	—	298
21	Colchicine	—	300
22	cycloheximide	—	300
23	deguelin [Supplementary Concept]	—	151
24	Digoxin	—	299
25	Disulfiram	—	297
26	Emetine	—	298
27	Ezetimibe	—	296
28	Lovastatin	—	300
29	Medroxyprogesterone Acetate	—	299
30	Melphalan	—	300
31	Mometasone Furoate	—	292
32	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
33	Niclosamide	—	299
34	piceatannol	—	300
35	Podophyllotoxin	—	14
36	Thapsigargin	—	300
37	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
38	Trifluridine	—	295
39	fisetin	—	78
40	ag490	—	14
41	Axitinib	—	298
42	Azathioprine	—	300
43	Bortezomib	—	300
44	Maprotiline	—	299
45	Nocodazole Nocodazole is	—	215
46	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
47	Tripterygium	—	300
48	Vincristine	—	299
49	withaferin	—	300
50	Berberine	—	300

About the Role of LAT2/NTAL/LAB on calcium mobilization Pathway

The Role of LAT2/NTAL/LAB on calcium mobilization pathway is catalogued in Reactome (ID: R-HSA-2730905) and involves 8 genes. In the BiohacksAI corpus, 209 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, GRB2, LYN, PDPK1, PIK3CB.