What compounds affect the Chromatin modifying enzymes pathway?

271 compounds in the BiohacksAI corpus have documented interactions with genes in the Chromatin modifying enzymes pathway (Reactome ID: R-HSA-3247509). These compounds target 52 genes within this pathway.

What genes are in the Chromatin modifying enzymes pathway?

The Chromatin modifying enzymes pathway involves 52 genes. Key genes include: ASH2L, CARM1, CDK4, CREBBP, DOT1L, DPY30, EED, EHMT1, EHMT2, EP300.

Chromatin modifying enzymes

REACTOME PATHWAY

Reactome: R-HSA-324750952 genes271 compounds

The Chromatin modifying enzymes pathway (Reactome ID: R-HSA-3247509) involves 52 genes and is affected by 271 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ASH2L CARM1 CDK4 CREBBP DOT1L DPY30 EED EHMT1 EHMT2 EP300 EZH2 HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 JAK2 KAT2A KAT2B KDM1A KDM4A KDM4B KDM4C KDM5B KDM6B KMT2A KMT5A KMT5C NCOA1 NCOR1+22 more

Compounds Affecting Chromatin modifying enzymes

#	Compound	Targets Hit	Studies
1	s adenosylhomocysteine	—	300
2	Bortezomib	—	300
3	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
4	Camptothecin	—	300
5	Vorinostat	—	299
6	Disulfiram	—	297
7	pictilisib	—	25
8	Daunorubicin	—	298
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Quercetin	—	300
11	Cyproheptadine	—	299
12	Ursolic Acid	—	300
13	scriptaid	—	53
14	Trifluridine	—	295
15	streptonigrin	—	299
16	Valproic Acid	—	296
17	Butyric Acid	—	300
18	Celecoxib	—	295
19	Podophyllotoxin	—	14
20	withaferin	—	300
21	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
22	triolimus [Supplementary Concept]	—	33
23	Kaempferols	—	300
24	Rutin	—	300
25	Methylene Blue	—	200
26	Deferasirox	—	298
27	Lovastatin	—	300
28	Astemizole Antihistamine drug now withdrawn from	—	280
29	Hexachlorophene	—	300
30	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
31	Biotin	—	297
32	scutellarein	—	113
33	Resveratrol	—	298
34	egcg	—	300
35	Withania	—	500
36	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
37	tamarixetin	—	26
38	plumbagin [Supplementary Concept]	—	300
39	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
40	Dasatinib	—	299
41	Azathioprine	—	300
42	Methotrexate	—	289
43	Calcitriol	—	300
44	Colchicine	—	300
45	cycloheximide	—	300
46	Digoxin	—	299
47	Ethidium	—	300
48	Nocodazole Nocodazole is	—	215
49	Sorafenib	—	300
50	Tripterygium	—	300

About the Chromatin modifying enzymes Pathway

The Chromatin modifying enzymes pathway is catalogued in Reactome (ID: R-HSA-3247509) and involves 52 genes. In the BiohacksAI corpus, 271 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ASH2L, CARM1, CDK4, CREBBP, DOT1L.