What compounds affect the Semaphorin interactions pathway?

69 compounds in the BiohacksAI corpus have documented interactions with genes in the Semaphorin interactions pathway (Reactome ID: R-HSA-373755). These compounds target 17 genes within this pathway.

What genes are in the Semaphorin interactions pathway?

The Semaphorin interactions pathway involves 17 genes. Key genes include: ARHGAP35, CDK5, CDK5R1, CFL1, DPYSL2, ERBB2, FES, FYN, GSK3B, HSP90AA1.

Semaphorin interactions

REACTOME PATHWAY

Reactome: R-HSA-37375517 genes69 compounds

The Semaphorin interactions pathway (Reactome ID: R-HSA-373755) involves 17 genes and is affected by 69 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ARHGAP35 CDK5 CDK5R1 CFL1 DPYSL2 ERBB2 FES FYN GSK3B HSP90AA1 HSP90AB1 LIMK1 LIMK2 MET PTPRC RHOC ROCK2

Compounds Affecting Semaphorin interactions

#	Compound	Targets Hit	Studies
1	kenpaullone	—	8
2	Sorafenib	—	300
3	Crizotinib	—	298
4	egcg	—	300
5	sp600125	—	117
6	Dasatinib	—	299
7	Quercetin	—	300
8	alsterpaullone	—	12
9	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
10	indirubin	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
14	chrysin	—	300
15	fisetin	—	78
16	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
17	triolimus [Supplementary Concept]	—	33
18	monorden	—	8
19	gedunin	—	54
20	celastrol	—	300
21	Novobiocin	—	300
22	caffeic acid	—	300
23	Masoprocol	—	300
24	Tetracycline	—	300
25	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
26	ag490	—	14
27	Clotrimazole	—	296
28	Idarubicin	—	299
29	piceatannol	—	300
30	Nitroprusside	—	299
31	Oleanolic Acid	—	300
32	hydroxyfasudil [Supplementary Concept]	—	11
33	tyrphostin ag 1478	—	4
34	Afatinib	—	297
35	2-Chloroadenosine 2-Chloroadenosine.	—	300
36	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
37	Calcimycin	—	216
38	Calcitriol	—	300
39	Ciclopirox	—	88
40	cycloheximide	—	300
41	deguelin [Supplementary Concept]	—	151
42	Disulfiram	—	297
43	Hexachlorophene	—	300
44	Indazoles	—	300
45	Miconazole	—	298
46	specioside	—	6
47	Wortmannin	—	300
48	Kaempferols	—	300
49	Lithium Chloride	—	300
50	ly294002	—	11

About the Semaphorin interactions Pathway

The Semaphorin interactions pathway is catalogued in Reactome (ID: R-HSA-373755) and involves 17 genes. In the BiohacksAI corpus, 69 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ARHGAP35, CDK5, CDK5R1, CFL1, DPYSL2.