Recruitment of mitotic centrosome proteins and complexes

Q: What compounds affect the Recruitment of mitotic centrosome proteins and complexes pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Recruitment of mitotic centrosome proteins and complexes pathway (Reactome ID: R-HSA-380270). These compounds target 16 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-38027016 genes71 compounds

The Recruitment of mitotic centrosome proteins and complexes pathway (Reactome ID: R-HSA-380270) involves 16 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK1 CDK11A CDK11B CSNK1D CSNK1E HSP90AA1 NEK2 PLK1 PLK4 PRKACA TUBA1A TUBA4A TUBB TUBB4A TUBB4B YWHAG

Compounds Affecting Recruitment of mitotic centrosome proteins and complexes

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Podophyllotoxin	—	14
5	Vincristine	—	299
6	Demecolcine	—	246
7	Maytansine	—	300
8	Noscapine	—	300
9	vinblastine sulfate	—	81
10	Vorinostat	—	299
11	Quercetin	—	300
12	alsterpaullone	—	12
13	Crizotinib	—	298
14	pictilisib	—	25
15	Masoprocol	—	300
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	Clotrimazole	—	296
18	Disulfiram	—	297
19	Hexachlorophene	—	300
20	Idarubicin	—	299
21	Wortmannin	—	300
22	kenpaullone	—	8
23	indirubin	—	300
24	Sorafenib	—	300
25	Dasatinib	—	299
26	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
27	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
28	triolimus [Supplementary Concept]	—	33
29	monorden	—	8
30	gedunin	—	54
31	celastrol	—	300
32	Novobiocin	—	300
33	caffeic acid	—	300
34	Tetracycline	—	300
35	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
36	2-Chloroadenosine 2-Chloroadenosine.	—	300
37	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
38	ag490	—	14
39	Calcimycin	—	216
40	Calcitriol	—	300
41	Ciclopirox	—	88
42	cycloheximide	—	300
43	deguelin [Supplementary Concept]	—	151
44	Indazoles	—	300
45	Miconazole	—	298
46	piceatannol	—	300
47	Nitroprusside	—	299
48	specioside	—	6
49	Clofibrate	—	299
50	Fenofibrate	—	297

About the Recruitment of mitotic centrosome proteins and complexes Pathway

The Recruitment of mitotic centrosome proteins and complexes pathway is catalogued in Reactome (ID: R-HSA-380270) and involves 16 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK1, CDK11A, CDK11B, CSNK1D, CSNK1E.