What compounds affect the Centrosome maturation pathway?

71 compounds in the BiohacksAI corpus have documented interactions with genes in the Centrosome maturation pathway (Reactome ID: R-HSA-380287). These compounds target 16 genes within this pathway.

What genes are in the Centrosome maturation pathway?

The Centrosome maturation pathway involves 16 genes. Key genes include: CDK1, CDK11A, CDK11B, CSNK1D, CSNK1E, HSP90AA1, NEK2, PLK1, PLK4, PRKACA.

Centrosome maturation

REACTOME PATHWAY

Reactome: R-HSA-38028716 genes71 compounds

The Centrosome maturation pathway (Reactome ID: R-HSA-380287) involves 16 genes and is affected by 71 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK1 CDK11A CDK11B CSNK1D CSNK1E HSP90AA1 NEK2 PLK1 PLK4 PRKACA TUBA1A TUBA4A TUBB TUBB4A TUBB4B YWHAG

Compounds Affecting Centrosome maturation

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Podophyllotoxin	—	14
5	Vincristine	—	299
6	Demecolcine	—	246
7	Maytansine	—	300
8	Noscapine	—	300
9	vinblastine sulfate	—	81
10	Vorinostat	—	299
11	Quercetin	—	300
12	alsterpaullone	—	12
13	Crizotinib	—	298
14	pictilisib	—	25
15	Masoprocol	—	300
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	Clotrimazole	—	296
18	Disulfiram	—	297
19	Hexachlorophene	—	300
20	Idarubicin	—	299
21	Wortmannin	—	300
22	kenpaullone	—	8
23	indirubin	—	300
24	Sorafenib	—	300
25	Dasatinib	—	299
26	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
27	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
28	triolimus [Supplementary Concept]	—	33
29	monorden	—	8
30	gedunin	—	54
31	celastrol	—	300
32	Novobiocin	—	300
33	caffeic acid	—	300
34	Tetracycline	—	300
35	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
36	2-Chloroadenosine 2-Chloroadenosine.	—	300
37	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
38	ag490	—	14
39	Calcimycin	—	216
40	Calcitriol	—	300
41	Ciclopirox	—	88
42	cycloheximide	—	300
43	deguelin [Supplementary Concept]	—	151
44	Indazoles	—	300
45	Miconazole	—	298
46	piceatannol	—	300
47	Nitroprusside	—	299
48	specioside	—	6
49	Clofibrate	—	299
50	Fenofibrate	—	297

About the Centrosome maturation Pathway

The Centrosome maturation pathway is catalogued in Reactome (ID: R-HSA-380287) and involves 16 genes. In the BiohacksAI corpus, 71 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK1, CDK11A, CDK11B, CSNK1D, CSNK1E.