What compounds affect the VEGFR2 mediated vascular permeability pathway?

62 compounds in the BiohacksAI corpus have documented interactions with genes in the VEGFR2 mediated vascular permeability pathway (Reactome ID: R-HSA-5218920). These compounds target 8 genes within this pathway.

What genes are in the VEGFR2 mediated vascular permeability pathway?

The VEGFR2 mediated vascular permeability pathway involves 8 genes. Key genes include: AKT3, HSP90AA1, MAPKAP1, MLST8, MTOR, NOS3, PDPK1, RICTOR.

VEGFR2 mediated vascular permeability

REACTOME PATHWAY

Reactome: R-HSA-52189208 genes62 compounds

The VEGFR2 mediated vascular permeability pathway (Reactome ID: R-HSA-5218920) involves 8 genes and is affected by 62 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AKT3 HSP90AA1 MAPKAP1 MLST8 MTOR NOS3 PDPK1 RICTOR

Compounds Affecting VEGFR2 mediated vascular permeability

#	Compound	Targets Hit	Studies
1	torin 1	—	10
2	Ku 0063794 [Supplementary Concept]	—	7
3	triolimus [Supplementary Concept]	—	33
4	Calcimycin	—	216
5	Disulfiram	—	297
6	Idarubicin	—	299
7	Wortmannin	—	300
8	Sirolimus	—	300
9	Everolimus	—	297
10	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
11	monorden	—	8
12	gedunin	—	54
13	celastrol	—	300
14	Novobiocin	—	300
15	caffeic acid	—	300
16	Masoprocol	—	300
17	Tetracycline	—	300
18	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	Quercetin	—	300
21	2-Chloroadenosine 2-Chloroadenosine.	—	300
22	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
23	ag490	—	14
24	Calcitriol	—	300
25	Ciclopirox	—	88
26	Clotrimazole	—	296
27	cycloheximide	—	300
28	deguelin [Supplementary Concept]	—	151
29	Hexachlorophene	—	300
30	Indazoles	—	300
31	Miconazole	—	298
32	piceatannol	—	300
33	Nitroprusside	—	299
34	specioside	—	6
35	pictilisib	—	25
36	ly294002	—	11
37	Rotenone	—	300
38	Thapsigargin	—	300
39	alpelisib	—	227
40	amn082	—	29
41	Idazoxan	—	300
42	Niclosamide	—	299
43	tyrphostin 9	—	2
44	egcg	—	300
45	Ursolic Acid	—	300
46	Camptothecin	—	300
47	Dequalinium	—	136
48	Emetine	—	298
49	Epinephrine	—	299
50	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299

About the VEGFR2 mediated vascular permeability Pathway

The VEGFR2 mediated vascular permeability pathway is catalogued in Reactome (ID: R-HSA-5218920) and involves 8 genes. In the BiohacksAI corpus, 62 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, HSP90AA1, MAPKAP1, MLST8, MTOR.