What compounds affect the MAPK family signaling cascades pathway?

230 compounds in the BiohacksAI corpus have documented interactions with genes in the MAPK family signaling cascades pathway (Reactome ID: R-HSA-5683057). These compounds target 106 genes within this pathway.

What genes are in the MAPK family signaling cascades pathway?

The MAPK family signaling cascades pathway involves 106 genes. Key genes include: ADRM1, AGO2, ARAF, ARRB1, BCL2L1, BRAF, CAMK2B, CAMK2D, CDC42, CDK1.

MAPK family signaling cascades

REACTOME PATHWAY

Reactome: R-HSA-5683057106 genes230 compounds

The MAPK family signaling cascades pathway (Reactome ID: R-HSA-5683057) involves 106 genes and is affected by 230 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AGO2 ARAF ARRB1 BCL2L1 BRAF CAMK2B CAMK2D CDC42 CDK1 CHURC1-FNTB CSK DUSP5 EGFR ERBB2 ERBB3 ERBB4 FGF22 FGFR1 FGFR2 FGFR3 FGFR4 FLT3 FNTA FNTB FOXO3 FYN GRB2 GRIN1 GRIN2B+76 more

Compounds Affecting MAPK family signaling cascades

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Sorafenib	—	300
3	Dasatinib	—	299
4	sp600125	—	117
5	Axitinib	—	298
6	Reserpine	—	297
7	Crizotinib	—	298
8	Quercetin	—	300
9	alsterpaullone	—	12
10	Afatinib	—	297
11	tyrphostin ag 1478	—	4
12	kenpaullone	—	8
13	egcg	—	300
14	pd98059	—	7
15	pictilisib	—	25
16	Vemurafenib	—	298
17	Lovastatin	—	300
18	Clotrimazole	—	296
19	eliprodil	—	33
20	trametinib	—	296
21	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
22	ly294002	—	11
23	Disulfiram	—	297
24	vinblastine sulfate	—	81
25	Methylene Blue	—	200
26	Lithocholic Acid	—	300
27	ninhydrin	—	300
28	Masoprocol	—	300
29	plumbagin [Supplementary Concept]	—	300
30	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
31	withaferin	—	300
32	Methotrexate	—	289
33	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
34	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
35	tyrphostin ag 1295	—	1
36	Resveratrol	—	298
37	alpelisib	—	227
38	Sirolimus	—	300
39	hydroxyfasudil [Supplementary Concept]	—	11
40	Gliotoxin	—	300
41	Okadaic Acid	—	300
42	Diphenhydramine	—	14
43	Cinnarizine	—	299
44	Clofibrate	—	299
45	Ethoxyquin Antioxidant; also	—	180
46	Fenofibrate	—	297
47	Phenoxybenzamine	—	21
48	Podophyllotoxin	—	14
49	Sertraline	—	1,000
50	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300

About the MAPK family signaling cascades Pathway

The MAPK family signaling cascades pathway is catalogued in Reactome (ID: R-HSA-5683057) and involves 106 genes. In the BiohacksAI corpus, 230 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AGO2, ARAF, ARRB1, BCL2L1.