What compounds affect the Surfactant metabolism pathway?

108 compounds in the BiohacksAI corpus have documented interactions with genes in the Surfactant metabolism pathway (Reactome ID: R-HSA-5683826). These compounds target 5 genes within this pathway.

What genes are in the Surfactant metabolism pathway?

The Surfactant metabolism pathway involves 5 genes. Key genes include: ADORA2B, ADRA2A, ADRA2C, P2RY2, SLC34A2.

Surfactant metabolism

REACTOME PATHWAY

Reactome: R-HSA-56838265 genes108 compounds

The Surfactant metabolism pathway (Reactome ID: R-HSA-5683826) involves 5 genes and is affected by 108 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADORA2B ADRA2A ADRA2C P2RY2 SLC34A2

Compounds Affecting Surfactant metabolism

#	Compound	Targets Hit	Studies
1	Yohimbine	—	299
2	Clonidine	—	299
3	Oxymetazoline	—	298
4	Norepinephrine Precursor of epinephrine that is secreted by	—	298
5	Phentolamine	—	300
6	Idazoxan	—	300
7	Epinephrine	—	299
8	Phenylephrine	—	299
9	Mianserin	—	299
10	Dexmedetomidine	—	299
11	Rilmenidine Oxazole derivative that acts as	—	300
12	Naphazoline	—	298
13	Piperoxan	—	167
14	Aripiprazole	—	298
15	Bromocriptine	—	299
16	Cabergoline	—	299
17	Dihydroergotamine	—	299
18	Guanfacine	—	294
19	Pergolide	—	299
20	Tolazoline	—	300
21	Carvedilol	—	296
22	Tamsulosin	—	298
23	Fluoxetine	—	1,000
24	Quetiapine Fumarate	—	994
25	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
26	Lisuride	—	299
27	Dihydroergotamine	—	9
28	Emetine	—	298
29	Guanabenz	—	298
30	Loxapine	—	225
31	Metergoline	—	144
32	Metoclopramide	—	297
33	Phenoxybenzamine	—	21
34	Piribedil	—	300
35	Pramipexole	—	297
36	Promethazine	—	296
37	Trazodone	—	297
38	Amlodipine	—	1,000
39	Rutin	—	300
40	Amisulpride	—	298
41	Amoxapine	—	259
42	Astemizole Antihistamine drug now withdrawn from	—	280
43	Buspirone	—	299
44	Chlorhexidine	—	299
45	Dihydroergocornine	—	65
46	Ergotamine	—	299
47	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
48	Indoramin	—	250
49	lidoflazine	—	278
50	Maprotiline	—	299

About the Surfactant metabolism Pathway

The Surfactant metabolism pathway is catalogued in Reactome (ID: R-HSA-5683826) and involves 5 genes. In the BiohacksAI corpus, 108 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADORA2B, ADRA2A, ADRA2C, P2RY2, SLC34A2.