What compounds affect the G1 Phase pathway?

53 compounds in the BiohacksAI corpus have documented interactions with genes in the G1 Phase pathway (Reactome ID: R-HSA-69236). These compounds target 12 genes within this pathway.

What genes are in the G1 Phase pathway?

The G1 Phase pathway involves 12 genes. Key genes include: ABL1, CCNE2, CDK2, CDK4, CDK6, CDK7, CUL1, JAK2, LYN, PPP2CA.

G1 Phase

REACTOME PATHWAY

Reactome: R-HSA-6923612 genes53 compounds

The G1 Phase pathway (Reactome ID: R-HSA-69236) involves 12 genes and is affected by 53 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 CCNE2 CDK2 CDK4 CDK6 CDK7 CUL1 JAK2 LYN PPP2CA PTK6 SRC

Compounds Affecting G1 Phase

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Crizotinib	—	298
6	tyrphostin ag 1478	—	4
7	Afatinib	—	297
8	Quercetin	—	300
9	Adenosine Triphosphate	—	300
10	sp600125	—	117
11	indirubin	—	300
12	Axitinib	—	298
13	Avapritinib	—	246
14	Biotin	—	297
15	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
16	Imatinib Mesylate	—	300
17	triolimus [Supplementary Concept]	—	33
18	Genistein	—	300
19	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
20	pterostilbene	—	299
21	alpelisib	—	227
22	Nocodazole Nocodazole is	—	215
23	Oxytetracycline	—	300
24	Azauridine	—	300
25	Cladribine	—	297
26	Methylene Blue	—	200
27	2-Methoxyestradiol	—	300
28	Astemizole Antihistamine drug now withdrawn from	—	280
29	Azathioprine	—	300
30	Calcitriol	—	300
31	Camptothecin	—	300
32	Cytarabine	—	297
33	dihydrorotenone	—	13
34	Podophyllotoxin	—	14
35	streptonigrin	—	299
36	Trifluridine	—	295
37	Tripterygium	—	300
38	Resveratrol	—	298
39	Adenosine Monophosphate Adenine nucleotide containing	—	300
40	monorden	—	8
41	Niclosamide	—	299
42	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
43	chrysin	—	300
44	fisetin	—	78
45	Aurintricarboxylic Acid	—	184
46	Methylergonovine	—	14
47	candesartan cilexetil [Supplementary Concept]	—	300
48	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
49	ninhydrin	—	300
50	hydroxyfasudil [Supplementary Concept]	—	11

About the G1 Phase Pathway

The G1 Phase pathway is catalogued in Reactome (ID: R-HSA-69236) and involves 12 genes. In the BiohacksAI corpus, 53 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, CCNE2, CDK2, CDK4, CDK6.