What compounds affect the S Phase pathway?

121 compounds in the BiohacksAI corpus have documented interactions with genes in the S Phase pathway (Reactome ID: R-HSA-69242). These compounds target 50 genes within this pathway.

What genes are in the S Phase pathway?

The S Phase pathway involves 50 genes. Key genes include: ADRM1, AKT3, CCNA1, CCNE2, CDC25A, CDC25B, CDK2, CDK4, CDK7, CUL1.

S Phase

REACTOME PATHWAY

Reactome: R-HSA-6924250 genes121 compounds

The S Phase pathway (Reactome ID: R-HSA-69242) involves 50 genes and is affected by 121 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AKT3 CCNA1 CCNE2 CDC25A CDC25B CDK2 CDK4 CDK7 CUL1 DNA2 FEN1 GMNN GSK3B MYC PCNA PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7+20 more

Compounds Affecting S Phase

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	kenpaullone	—	8
4	alsterpaullone	—	12
5	Sorafenib	—	300
6	Quercetin	—	300
7	Aurintricarboxylic Acid	—	184
8	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	indirubin	—	300
11	Oleanolic Acid	—	300
12	sp600125	—	117
13	Disulfiram	—	297
14	Dasatinib	—	299
15	Methyldopa	—	297
16	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
17	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
18	chrysin	—	300
19	egcg	—	300
20	Vitamin K 3	—	300
21	plumbagin [Supplementary Concept]	—	300
22	Methylergonovine	—	14
23	ninhydrin	—	300
24	hydroxyfasudil [Supplementary Concept]	—	11
25	Colchicine	—	300
26	Rotenone	—	300
27	2-Methoxyestradiol	—	300
28	Nocodazole Nocodazole is	—	215
29	Astemizole Antihistamine drug now withdrawn from	—	280
30	Metergoline	—	144
31	Podophyllotoxin	—	14
32	triflupromazine hydrochloride	—	12
33	Vorinostat	—	299
34	Calcimycin	—	216
35	Digitoxin	—	300
36	Doxazosin	—	24
37	Ethinyl Estradiol	—	300
38	Hexachlorophene	—	300
39	Niclosamide	—	299
40	Duloxetine Hydrochloride	—	993
41	Oleic Acid	—	112
42	ag490	—	14
43	Azacitidine	—	298
44	Azacitidine	—	300
45	Calcifediol	—	300
46	Calcitriol	—	300
47	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
48	cinacalcet	—	298
49	Clotrimazole	—	296
50	Decitabine	—	298

About the S Phase Pathway

The S Phase pathway is catalogued in Reactome (ID: R-HSA-69242) and involves 50 genes. In the BiohacksAI corpus, 121 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AKT3, CCNA1, CCNE2, CDC25A.