What compounds affect the Metabolism of amino acids and derivatives pathway?

249 compounds in the BiohacksAI corpus have documented interactions with genes in the Metabolism of amino acids and derivatives pathway (Reactome ID: R-HSA-71291). These compounds target 71 genes within this pathway.

What genes are in the Metabolism of amino acids and derivatives pathway?

The Metabolism of amino acids and derivatives pathway involves 71 genes. Key genes include: ADRM1, AHCY, CBS, CTH, DDC, DLD, GAMT, GLS, GLUL, GNMT.

Metabolism of amino acids and derivatives

REACTOME PATHWAY

Reactome: R-HSA-7129171 genes249 compounds

The Metabolism of amino acids and derivatives pathway (Reactome ID: R-HSA-71291) involves 71 genes and is affected by 249 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 AHCY CBS CTH DDC DLD GAMT GLS GLUL GNMT GPT2 GSR HNMT IARS1 IDO1 INMT IYD KARS1 KYAT1 KYNU LARS1 LOC102724560 NNMT NQO1 OAZ1 ODC1 PAOX PHGDH PNMT PSMA1+41 more

Compounds Affecting Metabolism of amino acids and derivatives

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Disulfiram	—	297
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	Quercetin	—	300
7	Chlorhexidine	—	299
8	Aurintricarboxylic Acid	—	184
9	tyrphostin 9	—	2
10	Methyldopa	—	297
11	piceatannol	—	300
12	Suramin	—	300
13	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
14	Demeclocycline	—	297
15	Iodoacetamide	—	300
16	Dasatinib	—	299
17	Triiodothyronine	—	300
18	Calcimycin	—	216
19	2-Methoxyestradiol	—	300
20	Crizotinib	—	298
21	Dequalinium	—	136
22	Ticagrelor	—	299
23	tyrphostin ag 1478	—	4
24	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
25	Cisplatin	—	300
26	darapladib [Supplementary Concept]	—	44
27	pictilisib	—	25
28	Vemurafenib	—	298
29	Thyroxine	—	994
30	Afatinib	—	297
31	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
32	Estrone	—	300
33	Guanabenz	—	298
34	Methylergonovine	—	193
35	Methysergide	—	300
36	propionylpromazine hydrochloride	—	2
37	scriptaid	—	53
38	Thiorphan	—	300
39	Thyroxine	—	300
40	Vitamin K 3	—	300
41	egcg	—	300
42	Spermine	—	300
43	chrysin	—	300
44	alpha-Linolenic Acid	—	300
45	Ethidium	—	300
46	Hexachlorophene	—	300
47	Methylene Blue	—	200
48	Rotenone	—	300
49	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
50	plumbagin [Supplementary Concept]	—	300

About the Metabolism of amino acids and derivatives Pathway

The Metabolism of amino acids and derivatives pathway is catalogued in Reactome (ID: R-HSA-71291) and involves 71 genes. In the BiohacksAI corpus, 249 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AHCY, CBS, CTH, DDC.