What compounds affect the Regulation of IFNG signaling pathway?

110 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of IFNG signaling pathway (Reactome ID: R-HSA-877312). These compounds target 7 genes within this pathway.

What genes are in the Regulation of IFNG signaling pathway?

The Regulation of IFNG signaling pathway involves 7 genes. Key genes include: IFNG, JAK2, PTPN1, PTPN2, PTPN6, STAT1, SUMO1.

Regulation of IFNG signaling

REACTOME PATHWAY

Reactome: R-HSA-8773127 genes110 compounds

The Regulation of IFNG signaling pathway (Reactome ID: R-HSA-877312) involves 7 genes and is affected by 110 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

IFNG JAK2 PTPN1 PTPN2 PTPN6 STAT1 SUMO1

Compounds Affecting Regulation of IFNG signaling

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Ursolic Acid	—	300
3	Oleanolic Acid	—	300
4	celastrol	—	300
5	Methylene Blue	—	200
6	2-Methoxyestradiol	—	300
7	Camptothecin	—	300
8	Dasatinib	—	299
9	Azathioprine	—	300
10	Sorafenib	—	300
11	Podophyllotoxin	—	14
12	Tripterygium	—	300
13	Astemizole Antihistamine drug now withdrawn from	—	280
14	Cladribine	—	297
15	Trifluridine	—	295
16	Lithocholic Acid	—	300
17	streptonigrin	—	299
18	Dacarbazine	—	299
19	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
20	Anisomycin	—	247
21	Benzethonium Bactericidal cationic quaternary ammonium surfactant used as	—	96
22	Bortezomib	—	300
23	cycloheximide	—	300
24	Desoxycorticosterone Acetate	—	300
25	tyrphostin 9	—	2
26	Quercetin	—	300
27	Crizotinib	—	298
28	Econazole	—	299
29	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
30	Nocodazole Nocodazole is	—	215
31	Afatinib	—	297
32	alsterpaullone	—	12
33	Chlorhexidine	—	299
34	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	—	299
35	Clofarabine	—	298
36	Clotrimazole	—	296
37	Dactinomycin	—	297
38	darapladib [Supplementary Concept]	—	44
39	Daunorubicin	—	298
40	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
41	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
42	Epirubicin	—	300
43	Estrone	—	300
44	Ethinyl Estradiol	—	300
45	Fulvestrant	—	295
46	Idarubicin	—	299
47	Irinotecan	—	298
48	Levonorgestrel	—	292
49	Miconazole	—	298
50	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300

About the Regulation of IFNG signaling Pathway

The Regulation of IFNG signaling pathway is catalogued in Reactome (ID: R-HSA-877312) and involves 7 genes. In the BiohacksAI corpus, 110 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include IFNG, JAK2, PTPN1, PTPN2, PTPN6.