What compounds affect the AURKA Activation by TPX2 pathway?

73 compounds in the BiohacksAI corpus have documented interactions with genes in the AURKA Activation by TPX2 pathway (Reactome ID: R-HSA-8854518). These compounds target 15 genes within this pathway.

What genes are in the AURKA Activation by TPX2 pathway?

The AURKA Activation by TPX2 pathway involves 15 genes. Key genes include: AURKA, CDK1, CSNK1D, CSNK1E, HSP90AA1, NEK2, PLK1, PLK4, PRKACA, TUBA1A.

AURKA Activation by TPX2

REACTOME PATHWAY

Reactome: R-HSA-885451815 genes73 compounds

The AURKA Activation by TPX2 pathway (Reactome ID: R-HSA-8854518) involves 15 genes and is affected by 73 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

AURKA CDK1 CSNK1D CSNK1E HSP90AA1 NEK2 PLK1 PLK4 PRKACA TUBA1A TUBA4A TUBB TUBB4A TUBB4B YWHAG

Compounds Affecting AURKA Activation by TPX2

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Colchicine	—	300
3	Nocodazole Nocodazole is	—	215
4	Podophyllotoxin	—	14
5	Vincristine	—	299
6	Demecolcine	—	246
7	Maytansine	—	300
8	Noscapine	—	300
9	vinblastine sulfate	—	81
10	Vorinostat	—	299
11	Quercetin	—	300
12	kenpaullone	—	8
13	alsterpaullone	—	12
14	Sorafenib	—	300
15	pictilisib	—	25
16	Masoprocol	—	300
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	Clotrimazole	—	296
19	Disulfiram	—	297
20	Hexachlorophene	—	300
21	Idarubicin	—	299
22	Wortmannin	—	300
23	Axitinib	—	298
24	Crizotinib	—	298
25	Dasatinib	—	299
26	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
27	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
28	triolimus [Supplementary Concept]	—	33
29	monorden	—	8
30	gedunin	—	54
31	celastrol	—	300
32	Novobiocin	—	300
33	caffeic acid	—	300
34	Tetracycline	—	300
35	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
36	2-Chloroadenosine 2-Chloroadenosine.	—	300
37	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
38	ag490	—	14
39	Calcimycin	—	216
40	Calcitriol	—	300
41	Ciclopirox	—	88
42	cycloheximide	—	300
43	deguelin [Supplementary Concept]	—	151
44	Indazoles	—	300
45	Miconazole	—	298
46	piceatannol	—	300
47	Nitroprusside	—	299
48	specioside	—	6
49	indirubin	—	300
50	Clofibrate	—	299

About the AURKA Activation by TPX2 Pathway

The AURKA Activation by TPX2 pathway is catalogued in Reactome (ID: R-HSA-8854518) and involves 15 genes. In the BiohacksAI corpus, 73 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AURKA, CDK1, CSNK1D, CSNK1E, HSP90AA1.