What compounds affect the Regulation of signaling by CBL pathway?

210 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of signaling by CBL pathway (Reactome ID: R-HSA-912631). These compounds target 11 genes within this pathway.

What genes are in the Regulation of signaling by CBL pathway?

The Regulation of signaling by CBL pathway involves 11 genes. Key genes include: FYN, GRB2, HCK, LYN, PIK3CB, PIK3CD, PIK3R1, PIK3R2, PIK3R3, SYK.

Regulation of signaling by CBL

REACTOME PATHWAY

Reactome: R-HSA-91263111 genes210 compounds

The Regulation of signaling by CBL pathway (Reactome ID: R-HSA-912631) involves 11 genes and is affected by 210 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYN GRB2 HCK LYN PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 SYK YES1

Compounds Affecting Regulation of signaling by CBL

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	Dasatinib	—	299
3	tyrphostin ag 1478	—	4
4	ly294002	—	11
5	Sorafenib	—	300
6	Sirolimus	—	300
7	Crizotinib	—	298
8	alpelisib	—	227
9	torin 1	—	10
10	Quercetin	—	300
11	kenpaullone	—	8
12	Wortmannin	—	300
13	sp600125	—	117
14	Axitinib	—	298
15	Afatinib	—	297
16	Cladribine	—	297
17	Vemurafenib	—	298
18	Kaempferols	—	300
19	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
20	alsterpaullone	—	12
21	Ku 0063794 [Supplementary Concept]	—	7
22	Ouabain	—	300
23	Atorvastatin	—	1,000
24	Simvastatin	—	1,000
25	Methotrexate	—	289
26	Chlorhexidine	—	299
27	Clofarabine	—	298
28	Colchicine	—	300
29	cycloheximide	—	300
30	deguelin [Supplementary Concept]	—	151
31	Digoxin	—	299
32	Disulfiram	—	297
33	Emetine	—	298
34	Ezetimibe	—	296
35	Lovastatin	—	300
36	Medroxyprogesterone Acetate	—	299
37	Melphalan	—	300
38	Mometasone Furoate	—	292
39	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
40	Niclosamide	—	299
41	piceatannol	—	300
42	Podophyllotoxin	—	14
43	Thapsigargin	—	300
44	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
45	Trifluridine	—	295
46	fisetin	—	78
47	ag490	—	14
48	Azathioprine	—	300
49	Bortezomib	—	300
50	Maprotiline	—	299

About the Regulation of signaling by CBL Pathway

The Regulation of signaling by CBL pathway is catalogued in Reactome (ID: R-HSA-912631) and involves 11 genes. In the BiohacksAI corpus, 210 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, GRB2, HCK, LYN, PIK3CB.