EGR2 and SOX10-mediated initiation of Schwann cell myelination

Q: What compounds affect the EGR2 and SOX10-mediated initiation of Schwann cell myelination pathway?

59 compounds in the BiohacksAI corpus have documented interactions with genes in the EGR2 and SOX10-mediated initiation of Schwann cell myelination pathway (Reactome ID: R-HSA-9619665). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96196655 genes59 compounds

The EGR2 and SOX10-mediated initiation of Schwann cell myelination pathway (Reactome ID: R-HSA-9619665) involves 5 genes and is affected by 59 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CYP51A1 HDAC2 HMGCR SREBF2 YAP1

Compounds Affecting EGR2 and SOX10-mediated initiation of Schwann cell myelination

#	Compound	Targets Hit	Studies
1	Daunorubicin	—	298
2	Camptothecin	—	300
3	Atorvastatin	—	1,000
4	Colchicine	—	300
5	Resveratrol	—	298
6	Rotenone	—	300
7	Pueraria	—	300
8	Azacitidine	—	298
9	Azacitidine	—	300
10	cycloheximide	—	300
11	Dactinomycin	—	297
12	deguelin [Supplementary Concept]	—	151
13	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
14	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
15	Ouabain	—	300
16	Podophyllotoxin	—	14
17	Thapsigargin	—	300
18	Berberine	—	300
19	Genistein	—	300
20	2-Methoxyestradiol	—	300
21	Anisomycin	—	247
22	Antimycin	—	300
23	Azauridine	—	300
24	Benzalkonium Compounds	—	299
25	celastrol	—	300
26	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
27	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
28	dihydrorotenone	—	13
29	Emetine	—	298
30	Gliotoxin	—	300
31	Homoharringtonine Semisynthetic derivative of harringtonine that acts as	—	300
32	Monensin	—	300
33	Monocrotaline	—	300
34	Nigericin	—	300
35	Nocodazole Nocodazole is	—	215
36	Plicamycin	—	72
37	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300
38	Tilorone	—	300
39	Tripterygium	—	300
40	Tubercidin	—	300
41	tyrphostin 9	—	2
42	Valinomycin	—	300
43	Vorinostat	—	299
44	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
45	scriptaid	—	53
46	pictilisib	—	25
47	Valproic Acid	—	296
48	Butyric Acid	—	300
49	Ursolic Acid	—	300
50	Bortezomib	—	300

About the EGR2 and SOX10-mediated initiation of Schwann cell myelination Pathway

The EGR2 and SOX10-mediated initiation of Schwann cell myelination pathway is catalogued in Reactome (ID: R-HSA-9619665) and involves 5 genes. In the BiohacksAI corpus, 59 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CYP51A1, HDAC2, HMGCR, SREBF2, YAP1.