What compounds affect the Leishmania infection pathway?

382 compounds in the BiohacksAI corpus have documented interactions with genes in the Leishmania infection pathway (Reactome ID: R-HSA-9658195). These compounds target 45 genes within this pathway.

What genes are in the Leishmania infection pathway?

The Leishmania infection pathway involves 45 genes. Key genes include: ABL1, ADAM17, ADCY9, ADORA2B, APP, BTK, CASP1, CDC42, CREB1, CTSG.

Leishmania infection

REACTOME PATHWAY

Reactome: R-HSA-965819545 genes382 compounds

The Leishmania infection pathway (Reactome ID: R-HSA-9658195) involves 45 genes and is affected by 382 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ABL1 ADAM17 ADCY9 ADORA2B APP BTK CASP1 CDC42 CREB1 CTSG CYSLTR1 CYSLTR2 ENTPD5 FGR FURIN FYN GNAI1 GNAS GRB2 GSDMD HCK HSP90AB1 IL1B IL6 JUN LYN MAPK1 MAPK14 MAPK3 MAPK8+15 more

Compounds Affecting Leishmania infection

#	Compound	Targets Hit	Studies
1	tyrphostin ag 1478	—	4
2	Dasatinib	—	299
3	Sorafenib	—	300
4	Quercetin	—	300
5	Disulfiram	—	297
6	Crizotinib	—	298
7	kenpaullone	—	8
8	Bortezomib	—	300
9	withaferin	—	300
10	Kaempferols	—	300
11	alsterpaullone	—	12
12	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
15	sp600125	—	117
16	Niclosamide	—	299
17	Podophyllotoxin	—	14
18	Axitinib	—	298
19	Afatinib	—	297
20	egcg	—	300
21	Resveratrol	—	298
22	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
23	cycloheximide	—	300
24	Trifluridine	—	295
25	Nocodazole Nocodazole is	—	215
26	Cladribine	—	297
27	Ethinyl Estradiol	—	300
28	Hexachlorophene	—	300
29	Nisoldipine	—	297
30	Ethidium	—	300
31	Masoprocol	—	300
32	Anisomycin	—	247
33	hydroxyfasudil [Supplementary Concept]	—	11
34	Chlorhexidine	—	299
35	Digoxin	—	299
36	Lovastatin	—	300
37	fisetin	—	78
38	alpelisib	—	227
39	Methylene Blue	—	200
40	celastrol	—	300
41	Clotrimazole	—	296
42	Daunorubicin	—	298
43	Digitoxin	—	300
44	monorden	—	8
45	pictilisib	—	25
46	triolimus [Supplementary Concept]	—	33
47	trequinsin hydrochloride	—	1
48	vinblastine sulfate	—	81
49	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
50	daph	—	2

About the Leishmania infection Pathway

The Leishmania infection pathway is catalogued in Reactome (ID: R-HSA-9658195) and involves 45 genes. In the BiohacksAI corpus, 382 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABL1, ADAM17, ADCY9, ADORA2B, APP.